Recent findings in adenoma described by researchers from Emory University, Medical Department
2009 JUL 6 - (NewsRx.com) -- According to recent research from the United States, "Inactivation of the tumor suppressor adenomatous polyposis coli, with the resultant activation of beta-catenin, is the initiating event in the development of a majority of colorectal cancers. Kruppel-like factor 5 (KLF5), a proproliferative transcription factor, is highly expressed in the proliferating intestinal crypt epithelial cells." "To determine whether KLF5 contributes to intestinal adenoma formation, we examined tumor burdens in Apc(Min/+) mice and Apc(Min/+)/Klf5(+/-) mice. Compared with Apc(Min/+) mice, Apc(Min/+)/Klf5(+/-) mice had a 96% reduction in the number of intestinal adenomas. Reduced tumorigenicity in the Apc(Min/+)/Klf5(+/-) mice correlated with reduced levels and nuclear localization of beta-catenin as well as reduced expression of two beta-catenin targets, cyclin D1 and c-Myc. In vitro studies revealed a physical interaction between KLF5 and beta-catenin that enhanced the nuclear localization and transcriptional activity of beta-catenin," wrote B.B. Mcconnell and colleagues, Emory University, Medical Department. The researchers concluded: "Thus, KLF5 is necessary for the tumor-initiating activity of beta-catenin during intestinal adenoma formation in Apc(Min/+) mice, and reduced expression of KLF5 offsets the tumor-initiating activity of the Apc(Min) mutation by reducing the nuclear localization and activity of beta-catenin. [Cancer Res 2009;69(10):4125-33]'." Mcconnell and colleagues published their study in Cancer Research (Haploinsufficiency of Kruppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the Apc(Min) Mutation in the Intestine. Cancer Research, 2009;69(10):4125-4133). For additional information, contact V.W. Yang, Emory University, School Medical, Dept. of Medical, Division Digestive Diseases, 201 Whitehead Research Bldg, 615 Michael St., Atlanta, GA 30322, USA. Publisher contact information for the journal Cancer Research is: American Association Cancer Research, 615 Chestnut St., 17TH Floor, Philadelphia, PA 19106-4404, USA. Keywords: United States, Atlanta, Adenomatous Polyposis Coli, Cancer Research, Colon Cancer, Colon Carcinoma, Colorectal, Endocrinology, Gastroenterology, Oncology, Tumor Suppression, Emory University, Medical Department. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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