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Researchers at Karolinska University target metabolism
2009 AUG 3 - (NewsRx.com) -- According to a study from Stockholm, Sweden, "The endogenous factors contributing to long-term changes in body weight are not known but the regulation of energy metabolism by different beta-adrenoceptors (beta(1)-AR, beta(2)-AR, beta(3)-AR) or alpha-adrenoceptors (alpha(2)-AR) may play a role. In a prospective study, we investigated beta-AR and alpha(2)-AR subtype function in subcutaneous fat cells of 85 healthy, non-obese women by using a standardized bioassay of lipolysis." "Of these 73 were re-investigated on an average 10 years later to compare baseline function of beta(1)-AR, beta(2)-AR, beta(3)-AR and alpha(2)-AR with longitudinal weight changes. Weight change over time was normally distributed ranging from -4 kg/m(2) to +6 kg/m(2) in body mass index. Long-term changes in body weight correlated inversely with b3-AR function at base line (r = 0.5, P = 0.001). Those with low beta(3)_AR function gained weight, whereas the opposite was observed with those who had a high b3-AR function. Nineteen percent of weight changes could be explained by beta(3)-AR status. No relationship with weight changes was observed as regards the function of alpha(2)-AR, beta(1)-AR or beta(2)-AR function. beta(3)-ARs are important for long-term changes in body weight putting energy metabolism in adipose tissue in frontline among endogenous factors that regulate body weight in adulthood," wrote D. Andersson and colleagues, Karolinska University. The researchers concluded: "International Journal of Obesity (2009) 33, 662-668; doi: 10.1038/ijo.2009.54; published online 14 April 2009'." Andersson and colleagues published the results of their research in International Journal of Obesity (beta 3-Adrenoceptor function and long-term changes in body weight. International Journal of Obesity, 2009;33(6):662-668). For additional information, contact P. Lofgren, Karolinska University Hospital, Karolinska Institute, Dept. of Medical, CME, M63, SE-14186 Stockholm, Sweden. The publisher of the International Journal of Obesity can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St., London N1 9XW, England. Keywords: Sweden, Stockholm, Adrenergic beta-Agonist, Bariatrics, Bronchodilator, Dobutamine Hydrochloride, Drugs, Metabolism, Obesity, Pharmaceuticals, Sympathomimetic, Terbutaline, Therapy, Tocolytic Agent, Treatment, Wellness, Karolinska University. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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