Adipose Tissue
Return to Library
|
Free Adipose Tissue Articles |
|
|
|
|
Reports on steatosis findings from H.P. Guan and co-researchers provide new insights
2009 OCT 26 - (NewsRx.com) -- According to recent research published in the Journal of Biological Chemistry, "The accumulation of triglycerides (TG) in the liver, designated hepatic steatosis, is characteristically associated with obesity and insulin resistance, but it can also develop after fasting. Here, we show that fasting-induced hepatic steatosis is under genetic control in inbred mice." "After a 24-h fast, C57BL/6J mice and SJL/J mice both lost more than 20% of body weight and similar to 60% of total body TG. In C57BL/6J mice, TG accumulated in liver, producing frank steatosis. In striking contrast, SJL/J mice failed to accumulate any hepatic TG even though they lost nearly as much adipose tissue mass as the C57BL/6J mice. Mice from five other inbred strains developed fasting-induced steatosis like the C57BL/6J mice. Measurements of the uptake of free fatty acids (FA) in vivo and in vitro demonstrated that SJL/J mice were protected from steatosis because their heart and skeletal muscle took up and oxidized twice as much FA as compared with C57BL/6J mice. As a result of this muscle diversion, serum-free FA and ketone bodies rose much less after fasting in SJL/J mice as compared with C57BL/6J mice. When livers of SJL/J and C57BL/6J mice were perfused with similar concentrations of FA, the livers took up and esterified similar amounts," wrote H.P. Guan and colleagues. The researchers concluded: "SJL/J mice express one or more variant genes that lead to enhanced FA uptake and oxidation in muscle, thereby sparing the liver from FA overload in the fasting state." Guan and colleagues published their study in the Journal of Biological Chemistry (Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice. Journal of Biological Chemistry, 2009;284(36):24644-24652). For additional information, contact J.L. Goldstein, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. The publisher's contact information for the Journal of Biological Chemistry is: American Society Biochemistry Molecular Biology Inc., 9650 Rockville Pike, Bethesda, MD 20814-3996, USA. Keywords: United States, Dallas, Bariatrics, Biological Chemistry, Insulin, Insulin Resistance, Obesity, Steatosis. This article was prepared by Diabetes Week editors from staff and other reports. Copyright 2009, Diabetes Week via NewsRx.com.
|
