Adipose Tissue

Study results from T. Ezure et al provide new insights into adipose tissue

Adipose Tissue Library Library Home This article was published in Obesity & Diabetes Week, which you can subscribe to online.

"In the early phase of adipogenesis, heat stimulation almost completely blocked the increase of CCAAT/enhancer binding protein delta (C/EBPdelta) gene expression and delayed the onset of the increase of C/EBPbeta gene expression. The expression of proliferator-activated receptor gamma (PPARgamma), which is regulated by these factors, was also reduced. In the later phase of adipogenesis, the induction of adipocyte-specific genes, such as C/EBPalpha, adipocyte protein 2 (aP2), lipoprotein lipase (LPL), adiponectin, and glucose transporter 4 (Glut4), which are regulated by PPARgamma, was reduced. However, adipogenesis was not significantly reduced if heat stimulation was carried out after the early phase of adipogenesis," wrote T. Ezure and colleagues.

The researchers concluded: "These results suggest that heat stimulation reduces adipogenesis by decreasing the expression of adipogenesis-related transcriptional factors during early adipogenesis.."

Ezure and colleagues published their study in Endocrine (Heat stimulation reduces early adipogenesis in 3T3-L1 preadipocytes. Endocrine, 2009;35(3):402-408).

For additional information, contact T. Ezure, Shiseido Research Center, Tsuzuki Ku, 2-2-1 Hayabuchi, Yokohama, Kanagawa 2248558, Japan.

Publisher contact information for the journal Endocrine is: Humana Press Inc., 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA.

Keywords: Japan, Yokohama, Adipose Tissue, Adipogenesis, Bariatrics, Endocrine, Obesity.

This article was prepared by Obesity & Diabetes Week editors from staff and other reports. Copyright 2009, Obesity & Diabetes Week via NewsRx.com.