Study results from Monash University in the area of enzyme research published
2009 AUG 3 - (NewsRx.com) -- "Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during prolonged moderate-intensity exercise. Hormone sensitive lipase (HSL) was long considered to be the rate-limiting enzyme for adipocyte and skeletal muscle TG lipolysis," investigators in Clayton, Australia report. "However, the understanding of TG lipolysis regulation was recently challenged by the finding that adipose TG lipase (ATGL) is the predominant TG lipase in adipose tissue and an important regulator of TG degradation in skeletal muscle. Thus, it is now proposed that ATGL and HSL regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of TG. Further to this biochemical evaluation, the generation and metabolic characterization of ATGL(-/-) and HSL-/- mice have revealed distinct phenotypes. ATGL(-/-) mice are obese, exhibit impaired thermogenesis, oxidize more carbohydrate, and die prematurely due to cardiac dysfunction. Studies in HSL-/- mice report defective beta-adrenergic stimulated lipolysis, protection against high-fat diet-induced obesity, and possible impairments in insulin secretion," wrote M.J. Watt and colleagues, Monash University. The researchers concluded: "This review outlines the current understanding of the cellular regulation of TG lipases, lipolytic regulation, and the functional implications of manipulating ATGL and HSL in vivo.." Watt and colleagues published their study in Applied Physiology Nutrition and Metabolism - Physiologie Appliquee Nutrition Et Metabolisme (Triglyceride lipases alter fuel metabolism and mitochondrial gene expression. Applied Physiology Nutrition and Metabolism - Physiologie Appliquee Nutrition Et Metabolisme, 2009;34(3):340-347). For additional information, contact M.J. Watt, Monash University, Dept. of Physiol, Clayton, Vic 3168, Australia. The publisher of the journal Applied Physiology Nutrition and Metabolism - Physiologie Appliquee Nutrition Et Metabolisme can be contacted at: National Research Council Canada-N R C Research Press, Building M 55, Ottawa, on K1A 0R6, Canada. Keywords: Australia, Clayton, Alternative Medicine, Applied Physiology, Diabetes, Enzyme Research, Hormones, Lipase, Metabolism, Obesity, Therapy, Treatment, Monash University. This article was prepared by Obesity & Diabetes Week editors from staff and other reports. Copyright 2009, Obesity & Diabetes Week via NewsRx.com.
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