Studies from Royal Liverpool University have provided new information about inflammation
2009 AUG 3 - (NewsRx.com) -- "Inflammation occurs in adipose tissue in obesity. We have examined whether IL-33, a recently identified IL-1 gene family member, and its associated receptors are expressed In human adipocytes," researchers in Liverpool, the United Kingdom report. "IL-33, IL-1RL1 and IL-1RAP gene expression was observed in human visceral white far, in preadipocytes and in adipocytes (SGBS cells). Treatment with TNF alpha for 24 h induced a 6-fold increase in IL-33 mRNA level in preadipocytes and adipocytes. Time-course studies with adipocytes showed that the increase in IL-33 mRNA with TNF alpha was maximal (>55-fold) at 12 h. This response was markedly different to IL-1 beta (peak mRNA increase at 2 h; 5.4-fold) and IL-18 (peak mRNA increase at 6 h: >1500-fold). Exposure of adipocytes to hypoxia (1% O-2, 24 h) did not alter IL-33 mRNA level: in preadipocytes, however, there was a 3-fold increase," wrote I.S. Wood and colleagues, Royal Liverpool University. The researchers concluded: "Human adipocytes and preadipocytes express IL-33, but the various IL-1 family members exhibit major differences in responsiveness to TNF alpha." Wood and colleagues published their study in Biochemical and Biophysical Research Communications (IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochemical and Biophysical Research Communications, 2009;384(1):105-109). For additional information, contact I.S. Wood, University of Liverpool, Royal Liverpool University Hospital, Obes Biology Research Unit, School Clinic Science, University of Clinic Department, Liverpool L69 3GA, Merseyside, UK. Publisher contact information for the journal Biochemical and Biophysical Research Communications is: Academic Press Inc. Elsevier Science, 525 B St., Ste. 1900, San Diego, CA 92101-4495, USA. Keywords: United Kingdom, Liverpool, Bariatrics, Biochemical, Inflammation, Obesity, Royal Liverpool University. This article was prepared by Obesity & Diabetes Week editors from staff and other reports. Copyright 2009, Obesity & Diabetes Week via NewsRx.com.
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