Scientists at University of Nottingham discuss research in metabolism
2009 AUG 3 - (NewsRx.com) -- According to a study from Loughborough, the United Kingdom, "Dietary conjugated linoleic acids (CLA) have been reported to have a number of isomer-dependent effects on lipid metabolism including reduction in adipose tissue deposition, changes in plasma lipoprotein concentrations and hepatic lipid accumulation. The aim of this study was to compare the effect of individual CLA isomers against lipogenic and high 'Western' fat background diets." "Golden Syrian hamsters were fed a high-carbohydrate rodent chow or chow supplemented with 17.25% fat formulated to represent the type and amount of fatty acids found in a typical 'Western' diet (including 0.2% cholesterol). Diets were further supplemented with 0.25% (w/w) rapeseed oil, cis9, trans11 (c9,t11)-CLA or trans10, cis12 (t10,c12)-CLA. Neither isomer had a significant impact on plasma lipid or lipoprotein concentrations. The t10,c12-CLA isomer significantly reduced perirenal adipose tissue depot mass. While adipose tissue acetyl CoA carboxylase and fatty acid synthase mRNA concentrations (as measured by quantitative PCR) were unaffected by CLA, lipoprotein lipase mRNA was specifically reduced by t10,c12-CLA, on both back.-round diets (P <0.001). This was associated with a specific reduction of sterol regulatory element binding protein 1c expression in perirenal adipose tissue (P=0.018). The isomers appear to have divergent effects on liver TAG content with c9,t11-CLA producing lower concentrations than t10,c12-CLA," wrote E.J. Tarling and colleagues, University of Nottingham. The researchers concluded: "T10,c12-CLA modestly reduces adipose tissue deposition in the Golden Syrian hamster independently of background diet and this may possibly result from reduced uptake of lipoprotein fatty acids, as a consequence of reduced lipoprotein lipase gene expression." Tarling and colleagues published their study in British Journal of Nutrition (Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets. British Journal of Nutrition, 2009;101(11):1630-1638). For more information, contact A.M. Salter, University of Nottingham, School Bioscience, Division Nutrition Science, Sutton Bonington Campus, Loughborough LE12 5RD, Leics, UK. Publisher contact information for the British Journal of Nutrition is: Cambridge University Press, Edinburgh Bldg, Shaftesbury Rd., CB2 8RU Cambridge, England. Keywords: United Kingdom, Loughborough, Alternative Medicine, Enzyme Research, Lipase, Metabolism, Therapy, Treatment, University of Nottingham. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2009, Proteomics Weekly via NewsRx.com.
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