Research on life sciences described by M. Doghman and colleagues
2009 JUL 20 - (NewsRx.com) -- According to recent research from Valbonne, France, "Transcription factor steroidogenic factor-1 (SF-1) plays a pivotal role in the control of adrenocortical cell steroidogenesis and proliferation. SF-1 amplification and overexpression are found in most cases of childhood adrenocortical tumors (ACTs)." "Our objective was to investigate the effect of SF-1 inverse agonists of the alkyloxyphenol and isoquinolinone classes on the proliferation of human adrenocortical cell lines expressing SF-1 (H295R), in conditions of basal and increased SF-1 expression, or negative for SF-1 expression (SW-13). Proliferation assays, immunoblots, flow cytometric analyses, steroid hormone assays, and reverse transcription quantitative PCR were used. SF-1 inhibitors of the alkyloxyphenol class displayed a dose-dependent inhibitory effect on both SF-1-positiveand-negative ACT cells, whereas SF-1 inverse agonists of the isoquinolinone class selectively inhibited cell proliferation elicited by SF-1 overexpression. These drugs also inhibited stimulated steroid hormone secretion and CYP21 and CYP17 mRNA expression," wrote M. Doghman and colleagues. The researchers concluded: "SF-1 inhibitors may represent a useful tool in the chemotherapy of ACTs. (J Clin Endocrinol Metab 94: 2178-2183, 2009)'." Doghman and colleagues published their study in the Journal of Clinical Endocrinology & Metabolism (Inhibition of Adrenocortical Carcinoma Cell Proliferation by Steroidogenic Factor-1 Inverse Agonists. Journal of Clinical Endocrinology & Metabolism, 2009;94(6):2178-2183). For additional information, contact E. Lalli, CNRS, Institute Pharmacology Molecular & Cellulaire, UMR 6097, 660 Route Lucioles, F-06560 Valbonne, France. Publisher contact information for the Journal of Clinical Endocrinology & Metabolism is: Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817, USA. Keywords: France, Valbonne, Life Sciences, Adrenocortical Cancer, Adrenocortical Carcinoma, Oncology, Clinical Endocrinology, Cell Proliferation, Metabolism. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.
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