Adrenoleukodystrophy
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Researchers from National Institute of Mental Health publish new studies and findings in the area of adrenoleukodystrophy
2009 AUG 24 - (NewsRx.com) -- New research, 'Early signs of visual perception and evoked potentials in radiologically asymptomatic boys with X-linked adrenoleukodystrophy,' is the subject of a report. According to recent research published in the Journal of Child Neurology, "The aim was to identify the electrophysiological and psychological signs at a very early stage in asymptomatic boys with childhood cerebral X-linked adrenoleukodystrophy. Flash visual evoked potentials, pattern reversal, and visual event-related potentials were recorded in 6 radiologically asymptomatic boys with adrenoleukodystrophy and 22 control boys." "The latency and amplitude of P100 of visual evoked potentials and P1 of event-related potentials were evaluated. Though all patients had normal intelligence quotient, performance intelligence quotient was significantly lower than verbal intelligence quotient in 2 patients. Both P100 and P1 amplitudes were significantly greater in adrenoleukodystrophy than in controls. The difference between performance intelligence quotient and verbal intelligence quotient exhibited significant correlation with P100 amplitude. Enlargement of visual evoked potentials might be a sign of cerebral involvement preceding the appearance of abnormalities on magnetic resonance imaging," wrote W. Furushima and colleagues, National Institute of Mental Health. The researchers concluded: "Follow-up of asymptomatic boys with both electrophysiological and neuropsychological tests may serve as an aid for deciding the timing of therapeutic intervention." Furushima and colleagues published their study in the Journal of Child Neurology (Early signs of visual perception and evoked potentials in radiologically asymptomatic boys with X-linked adrenoleukodystrophy. Journal of Child Neurology, 2009;24(8):927-35). For additional information, contact W. Furushima, National Institute of Mental Health, Dept. of Developmental Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan. The publisher's contact information for the Journal of Child Neurology is: SAGE Publications, USA , 2455 Teller Road, Thousand Oaks, CA 91320, USA. Keywords: Japan, Tokyo, Adrenoleukodystrophy, Child Neurology, Mental Health, Physiology, Psychology, Urology. This article was prepared by Mental Health Weekly Digest editors from staff and other reports. Copyright 2009, Mental Health Weekly Digest via NewsRx.com.
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