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Studies from M.A. Al Ansary and colleagues reveal new findings on clinical trial research
2009 AUG 3 - (NewsRx.com) -- Investigators publish new data in the report 'Interventions for treating traumatized necrotic immature permanent anterior teeth: inducing a calcific barrier & root strengthening.' "Apical barrier formation and root strengthening procedures have been extensively described in the literature. This systematic review attempts to establish where the effects of interventions using multi-visit apexification, single visit apical plug techniques and root strengthening procedures are consistent and where they may vary significantly," researchers in Kuwait report. "To evaluate the relative effectiveness of apexification and apical plug techniques as well as root strengthening procedures for treating traumatized necrotic immature permanent anterior teeth through a systematic review of randomized controlled trials. Reported immediate and/or long-term adverse events and effects of the materials and techniques are also evaluated. SEARCH STRATEGY & SELECTION CRITERIA: Structured electronic and hand search was performed with no restriction on the language of publication. Only randomized controlled trials comparing different apical barrier formation techniques and root strengthening procedures in traumatized necrotic immature anterior teeth were assessed. Two hundred studies were identified but only two were suitable for inclusion. Included studies investigated multi-visit apexification techniques using calcium hydroxide and tricalcium phosphate. There were no eligible studies investigating root strengthening procedures or any other intervention for apical barrier formation in necrotic immature anterior teeth. No reliable information was available on long-term adverse effects of the reported interventions or cost implications. Based on two included studies, there is weak evidence supporting the use of either calcium hydroxide or tricalcium phosphate for apical barrier formation in necrotic immature anterior teeth employing multi-visit apexification techniques. The evidence is insufficient to provide guidelines for practice," wrote Ansary M.A. Al and colleagues, . The researchers concluded: "There was no reliable evidence on adverse events or long-term effects after the use of calcium hydroxide or tricalcium phosphate justifying caution in their use in apical barrier formation techniques." Al and colleagues published their study in Dental Traumatology (Interventions for treating traumatized necrotic immature permanent anterior teeth: inducing a calcific barrier & root strengthening. Dental Traumatology, 2009;25(4):367-79). For additional information, contact M.A. Al Ansary, Bnied Al Gar Speciality Dental Centre, Paediatric Dentistry Department, Kuwait. Publisher contact information for the journal Dental Traumatology is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: Kuwait, Adverse Drug Effect, Adverse Drug Event, Adverse Drug Reaction, Clinical Trial Research, Therapy, Traumatology, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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