Aggressive Fibromatosis

New aggressive fibromatosis risk factors data have been reported by researchers at Nagoya University, Department of Orthopedic Surgery

Aggressive Fibromatosis Library Library Home This article was published in Disease Prevention Week, which you can subscribe to online.

"The purpose of this study was to analyze the clinical outcome of patients with extremity and trunk desmoid tumors after surgical treatment and to determine the factors influencing local recurrence. Between January 1991 and December 2003, 30 of 58 patients with desmoid tumors referred to our institutions and surgically treated and followed up for more than 2 years were selected for this study. Patient age, gender, tumor size, location, status of disease (primary or recurrent), and surgical margins were analyzed as possible risk factors for recurrence. Sixteen (53%) of the 30 patients had a local recurrence. Eight of the 19 patients (42.1%) with a negative surgical margin experienced a recurrence. Younger age (<30 years) was a significant risk factor for local recurrence (p <0.05). Tumor size, surgical margin and previous surgical history were not associated with local recurrence. Younger age and female gender had a propensity for local recurrence, suggesting that the biological behavior of desmoid tumor may depend on the status of the disease at presentation," wrote Y. Shido and colleagues, Nagoya University, Department of Orthopedic Surgery.

The researchers concluded: "These results suggest that radical surgical treatment causing severe functional impairment should be avoided in selected cases on the basis of patient characteristics, and that other novel therapeutic tools may be necessary for patients in whom a higher risk of local recurrence is assumed or severe complications after surgical treatment are predicted."

Shido and colleagues published their study in Archives of Orthopaedic and Trauma Surgery (Surgical treatment for local control of extremity and trunk desmoid tumors. Archives of Orthopaedic and Trauma Surgery, 2009;129(7):929-33).

For additional information, contact Y. Shido, Nagoya University Graduate School of Medicine, Dept. of Orthopedic Surgery, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

The publisher's contact information for the journal Archives of Orthopaedic and Trauma Surgery is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords: Japan, Nagoya, Aggressive Fibromatosis Risk Factors, Aggressive Fibromatosis, Gender Health, Gender Medicine, Orthopedics, Surgery, Women's Health.

This article was prepared by Disease Prevention Week editors from staff and other reports. Copyright 2009, Disease Prevention Week via NewsRx.com.