New data from T. Ferenc et al illuminate research in aggressive fibromatosis
2009 JUN 1 - (NewsRx.com) -- Scientists discuss in 'Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor)' new findings in aggressive fibromatosis. According to a study from Lodz, Poland, "The aims of this study were to analyze the cadherin/catenin adhesion complex in cells from abdominal and extra-abdominal aggressive fibromatosis tumors, and to estimate the correlation between the expression of the tested proteins and the clinical data of the desmoid patients. Immunohistochemistry was used to examine the expression of the cadherin/catenin adhesion complex: APC protein, alpha-, beta-catenin, and N-cadherin in archival material derived from 15 cases of extra-abdominal desmoid tumor (E-AD) and 20 cases of abdominal (AD) desmoid tumor." "The tested proteins demonstrated cytoplasmic (c) staining. Furthermore, nuclear (n) or cytoplasmic and nuclear (c+n) staining was observed for beta-catenin. The mean values of the percentage of positive cells for the tested proteins between E-AD vs. AD did not demonstrate any statistically significant difference except for alpha-catenin. In the E-AD group, in both cases of recurrent tumors, no alpha-catenin expression was observed but the expression of this protein was detected in primary tumors. In the groups investigated, no statistically significant correlation was found between alpha-catenin, beta-catenin (c), (n) and (c+n) expression, and tumor size (p >0.1)," wrote T. Ferenc and colleagues, . The researchers concluded: "The results regarding beta-catenin expression obtained in our study confirm the previous findings that nuclear accumulation of this protein plays a crucial role in the pathogenesis of aggressive fibromatosis." Ferenc and colleagues published their study in Pathology - Research and Practice (Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor). Pathology - Research and Practice, 2009;205(5):311-24). For more information, contact T. Ferenc, Medical University, Dept. of Biology and Genetics, Pl Hallera 1, 90-647 Lodz, Poland. Publisher contact information for the journal Pathology - Research and Practice is: Taylor & Francis Group Ltd, 2 Park Square, Milton Park, Abingdon, Oxford OX14 4RN United Kingdom. Keywords: Poland, Lodz, Aggressive Fibromatosis, Dermatology, Gastroenterology, Neurology, Pathology, Protein Expression, Proteins, Proteomics. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
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