Our news journalists obtained a quote from the research from the University of Southern California, "In women, menopause results in a relatively rapid loss of estradiol and progesterone. In men, aging is associated with a comparatively gradual yet significant decrease in testosterone. We review a broad literature that indicates age-related losses of estrogens in women and testosterone in men are risk factors for AD. Both estrogens and androgens exert a wide range of protective actions that improve multiple aspects of neural health, suggesting that hormone therapies have the potential to combat AD pathogenesis. However, translation of experimental findings into effective therapies has proven challenging. One emerging treatment option is the development of novel hormone mimetics termed selective estrogen and androgen receptor modulators."
According to the news editors, the research concluded: "Continued research of sex hormones and their roles in the aging brain is expected to yield valuable approaches to reducing the risk of AD."
For more information on this research see: Sex hormones, aging, and Alzheimer's disease. Frontiers In Bioscience, 2012;4():976-97.
Our news journalists report that additional information may be obtained by contacting A.M. Barron, USC Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, United States.
Keywords for this news article include: Dementia, Hormones, California, Los Angeles, Tauopathies, United States, Brain Diseases, Alzheimer Disease, North and Central America, Neurodegenerative Diseases, Central Nervous System Diseases.
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