Albuminuria

Data on neuropathy described by researchers at National University, Medical Department

Albuminuria Library Library Home This article was published in Pain & Central Nervous System Week, which you can subscribe to online.

"They studied 5,094 participants with fasting plasma glucose values and concurrent microvascular complications from 4 previous cross-sectional surveys carried out in Singapore (1982-1998) who attended a follow-up examination in 2004-2007. Peripheral neuropathy was diagnosed based on abnormal responses to a 10-g monofilament or neurothesiometer test. Chronic kidney disease was defined in various ways by using albuminuria (urine albumin:creatinine ratio > 30 mu g/mg) and estimated glomerular filtration rate, alone and in combination. Prevalence of peripheral neuropathy was 7.5%. For chronic kidney disease, prevalence of albuminuria only was 10.5%, estimated glomerular filtration rate of < 60 mL/minute per 1.73 m(2) only was 4.1%, and both was 2.1%. Prevalence of peripheral neuropathy and chronic kidney disease gradually increased in relation to fasting plasma glucose, beginning at levels below the existing diagnostic threshold for diabetes mellitus of 7.0 mmol/L (126 mg/dL). For chronic kidney disease, these associations persisted after adjustment for age, gender, ethnic group, and hypertension. Current diagnostic thresholds for diabetes mellitus have limited sensitivity for identifying individuals with these microvascular complications," wrote E.E.K. Nang and colleagues, National University, Medical Department.

The researchers concluded: "Ascertaining these individuals may require development and application of novel screening strategies."

Nang and colleagues published their study in American Journal of Epidemiology (Is There a Clear Threshold for Fasting Plasma Glucose That Differentiates Between Those With and Without Neuropathy and Chronic Kidney Disease' American Journal of Epidemiology, 2009;169(12):1454-1462).

For additional information, contact J. Lee, Singapore National University, Yong Loo Lin School Medical, Dept. of Community Occupational & Family Medical, MD3, 16 Med Dr., Singapore 117597, Singapore.

The publisher's contact information for the American Journal of Epidemiology is: Oxford University Press Inc., Journals Dept., 2001 Evans Rd., Cary, NC 27513, USA.

Keywords: Singapore, Singapore, Albuminuria, Chronic Disease, Endocrinology, Epidemiology, Insulin Dependent Diabetes Mellitus, Kidney Disease, Non-insulin Dependent Diabetes Mellitus, Ophthalmology, Peripheral Nervous System Disease, Peripheral Neuropathy, Retinopathy, Type 1 Diabetes, Type 2 Diabetes Mellitus, National University, Medical Department.

This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.