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Researchers at University of Naples Federico II Target Hemodialysis

2012 NOV 23 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Hemodialysis have been published. According to news reporting from Naples, Italy, by NewsRx journalists, research stated, "Serum concentrations of potassium (K) and calcium (Ca) influence ionic currents and play an important role in the duration of ventricular action potential. Further, the influence of alkalosis in reducing ionized calcium has been well known for a long time."

The news correspondents obtained a quote from the research from the University of Naples Federico II, "The aim of this study was to assess the effects of different dialysate electrolytes and bicarbonate concentrations on changes of QTc interval in patients on chronic hemodialysis. The study hemodialysis sessions were performed in 22 patients, with different electrolyte and bicarbonate concentrations in dialysate. Tested dialysate concentrations were K of 2 and 3 mmol/L; Ca 1.25, 1.5 and 1.75 mmol/L; and bicarbonate 30 and 34 mmol/L. An electrocardiogram (ECG) was recorded 1 hour before, at the end and every hour for 4 hours after each study dialysis session. QTc interval was measured from the beginning of the QRS complex to the end of a T wave on a 12-lead ECG. Blood was collected and K, total Ca, ionic Ca and pH evaluated. At the end of the study hemodialysis session with dialysate containing low K (2 mmol/L), low Ca (1.25 mmol/L) and high bicarbonate concentration (34 mmol), mean QTc interval was significantly prolonged compared with that recorded with dialysate containing high K (3 mmol/L), high Ca (1.75 mmol/L) and bicarbonate (30 mmol) (40 +/- 10 milliseconds vs. 2 +/- 2 milliseconds; p<0.01). Dialysate with low concentration of low Ca, K and high concentration of bicarbonate was an independent predictor of QTc; the combination of low Ca and K and high bicarbonate strongly increased the risk of prolonged QTc interval."

According to the news reporters, the research concluded: "The present pilot study shows that changes in QTc interval during hemodialysis depend on both electrolyte and bicarbonate concentrations in dialysate."

For more information on this research see: Dialysate bath and QTc interval in patients on chronic maintenance hemodialysis: pilot study of single dialysis effects. Journal of Nephrology, 2012;25(5):653-660. Journal of Nephrology can be contacted at: Wichtig Editore, 72, 74 Via Friuli, 20135 Milan, Italy.

Our news journalists report that additional information may be obtained by contacting B. Di Iorio, University of Naples Federico II, Dept. of Nephrol, Sch Med, Naples, Italy.

Keywords for this news article include: Ions, Italy, Naples, Europe, Bicarbonates, Electrolytes, Hemodialysis, Renal Dialysis, Inorganic Chemicals

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