Research on allergies published by scientists at Ruhr University, Institute of Occupational Medicine
2007 NOV 21 -- Research findings, 'Natural rubber latex and chestnut allergy: cross-reactivity or co-sensitization,' are discussed in a new report. According to a study from Bochum, Germany, "Chestnut and natural rubber latex (NRL) allergy are often associated in the latex-fruit syndrome To establish whether the concurrent NRL and chestnut IgE antibody reactivity are the results of co-sensitization or cross-reactivity Sera from 19 patients with chestnut-and NRL-specific IgE were selected and tested for reactivity with recombinant (r) latex allergens. Cross-reactivity was explored by IgE-inhibition experiments using chestnut or NRL allergens as solid phase on ImmunoCAP IgE-antibodies were detected to rHev b 6.01 (prohevein) in 58% of the sera, to rHev b 5 in 32%, to rHev b 12 in four of 13 sera, to rHev b 7.02 and rHev b 11 in four, and to rHev b 1 in two of 19 sera. rHev b 8-IgE antibodies were found in nine sera (47%), whereas six displayed mono-sensitization to rHev b 8 with regard to our test panel." "Three of 16 sera showed IgE to cross-reactive carbohydrate determinants. In most sera recognizing rHev b 5 and/or rHev b 6.01 as major allergens the IgE-reactivity to NRL remained unaffected by chestnut extract and chestnut-IgE remained unaffected by NRL extract. Conversely, in sera with rHev b 8 as dominant allergen IgE-binding to NRL was nearly completely inhibited by chestnut and vice versa," wrote M. Raulf-Heimsoth and colleagues, Ruhr University, Institute of Occupational Medicine. The researchers concluded: "IgE-binding to rHev b 8 was abolished by chestnut extract Although patients have concomitant IgE antibody reactivity to chestnut and NRL, cross-reactivity could be demonstrated mainly in those patients with IgE to Hev b 8 (profilin) from NRL." Raulf-Heimsoth and colleagues published their study in Allergy (Natural rubber latex and chestnut allergy: cross-reactivity or co-sensitization? Allergy, 2007;62(11):1277-81). For more information, contact M. Raulf-Heimsoth, Research Institute of Occupational Medicine of the Berufsgenossenschaften (BGFA), Ruhr-University Bochum, Bochum, Germany. Publisher contact information for the journal Allergy is: Blackwell Munksgaard, 35 Norre Sogade, PO Box 2148, DK-1016 Copenhagen, Denmark. Keywords: Germany, Bochum, Allergen, Allergies, Allergy Medicine. This article was prepared by Immunotherapy Weekly editors from staff and other reports. Copyright 2007, Immunotherapy Weekly via NewsRx.com.
|
