Ambiguous Genitalia
Return to Library
New urology research has been reported by scientists at Hokkaido University, Medical Department
2009 OCT 26 - (NewsRx.com) -- "We report the long-term outcome of vaginoplasty with the bilateral labioscrotal flap with special emphasis on vaginal stenosis. Of 23 children with ambiguous genitalia and low vaginal entry who underwent vaginoplasty between January 1985 and July 2003 with the bilateral labioscrotal flap 13 followed more than 5 years after surgery who were 10 years old or older at the most recent evaluation were included in this long-term outcome study," scientists writing in the Journal of Urology report. "Vaginal caliber was estimated according to a previously described assessment system adopted for vaginoplasty results. The underlying disease was congenital adrenal hyperplasia in 11 cases, mixed gonadal dysgenesis in 1 and ovotesticular sexual development disorder in 1. Mean age at vaginoplasty and at the most recent evaluation was 3.8 (range 2.0 to 12.9) and 14.6 years (range 10.9 to 21.5), respectively. Vaginal caliber at the most recent evaluation was adequate in 6 patients (46%), stenotic in 5 (39%) and strictured in 2 (15%). Three of the 7 patients diagnosed with stricture or stenosis were diagnosed at age less than 12 years. One of these patients diagnosed with stricture was treated with dilation and the other 2 patients were observed. These patients had no trouble with menstruation. Four patients diagnosed with stricture or stenosis at age 14 years or older were treated surgically with dilation in 1 and perineal flap vaginoplasty in 3. They showed adequate vaginal caliber at 3 to 31 months of followup. In 7 patients evaluated at the beginning of puberty and several years later vaginal caliber had enlarged in 5 but remained unchanged in 2. To our knowledge this is the first report of the long-term outcome of vaginoplasty with the bilateral labioscrotal flap. Although vaginal stenosis/stricture was observed at puberty in about half of the patients, severe stricture was uncommon," wrote K. Moriya and colleagues, Hokkaido University, Medical Department. The researchers concluded: "Serial evaluation for vaginal stenosis/stricture at the beginning of puberty for menstruation and several years later for vaginal intercourse is recommended in patients treated with vaginal reconstruction." Moriya and colleagues published their study in the Journal of Urology (Long-Term Outcome of Vaginoplasty With the Bilateral Labioscrotal Flap. Journal of Urology, 2009;182(4 Part 2):1876-1881). Additional information can be obtained by contacting K. Moriya, Hokkaido University, Graduate School Medical, Dept. of Urology, Kita Ku, North 15, West 7, Sapporo, Hokkaido 0600824, Japan. The publisher of the Journal of Urology can be contacted at: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA. Keywords: Japan, Sapporo, Life Sciences, Endocrinology, Genetics, Congenital Adrenal Hyperplasia, Sex Differentiation Disorder, Ambiguous Genitalia, Gonadal Dysgenesis, Angiology, Stenosis, Pediatrics, Surgery, Urology, Hokkaido University, Medical Department. This article was prepared by Gastroenterology Week editors from staff and other reports. Copyright 2009, Gastroenterology Week via NewsRx.com.
|
