Reports outline dentistry study results from University of Paris
2007 APR 24 -- A report, "Validation of amelogenesis imperfecta inferred from amelogenin evolution," is newly published data in Journal of Dental Research. "We used the evolutionary analysis of amelogenin (AMEL) in 80 amniotes (52 mammalian and 28 reptilian sequences) to aid in the genetic diagnosis of X-linked amelogenesis imperfecta (AIH1). Out of 191 residues, 77 were found to be unchanged in mammals, and only 34 in amniotes," investigators in Paris, France report. "The latter are considered crucial residues for enamel formation, while the 43 residues conserved only in mammals could indicate that they play new, important roles for enamel formation in this lineage. The 5 substitutions leading to AIH1 were validated when the mammalian dataset was used, and 4 of them with the amniote dataset. These 2 sequence datasets will facilitate the validation of any human AMEL mutation suspected of involvement in AIH1," wrote S. Delgado and colleagues, University of Paris. The researchers concluded: "This evolutionary analysis also revealed numerous residues that appeared to be important for correct AMEL function, but their role remains to be elucidated." Delgado and colleagues published their study in the Journal of Dental Research (Validation of amelogenesis imperfecta inferred from amelogenin evolution. Journal of Dental Research, 2007;86(4):326-30). For additional information, contact S. Delgado, Universite Paris 6, UMR 7138, Equipe Evolution & Developpement du Squelette, Case 05, 7 quai St-Bernard, 75005 Paris, France. The publisher of the Journal of Dental Research can be contacted at: International American Association Dental Researchi a D R, a a D R, 1619 Duke St., Alexandria, VA 22314-3406, USA. Keywords: France, Paris, Dentistry. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
|
