New research on metalloproteinase from University of Sao Paulo summarized
2007 APR 2 -- New investigation results, "The role of matrix metalloproteinases in the oral environment," are detailed in a study published in Acta Odontologica Scandinavica. According to recent research published in the journal Acta Odontologica Scandinavica, "This review focuses specifically on matrix metalloproteinases (MMPs) and their role in physiological and pathological extracellular matrix (ECM) remodeling and degradation processes in the oral environment. A group of enzymes capable of degrading almost all ECM proteins, MMPs contribute to both normal and pathological tissue remodeling." "The expression of different MMPs may be upregulated in pathological conditions such as inflammation and tumor invasion. The balance between activated MMPs and tissue inhibitors of metalloproteinases (TIMPs) controls the extent of ECM remodeling. Prior to mineralization, MMPs may participate in the organization of enamel and dentin organic matrix, or they may regulate mineralization by controlling the proteoglycan turnover. There is evidence indicating that MMPs could be involved in the etiology of enamel fluorosis and amelogenesis imperfecta. They seem to play a part in dentinal caries progression, since they have a crucial role in dentin collagen breakdown in caries lesions. MMPs have been identified in pulpal and periapical inflammation and are strongly correlated with periodontal diseases, since they are the major players in collagen breakdown during periodontal tissue destruction," wrote A.R. Hannas and colleagues, University of Sao Paulo. The researchers concluded: "The use of MMP inhibitors could help the prevention and treatment of many MMP-related oral diseases." Hannas and colleagues published their study in Acta Odontologica Scandinavica (The role of matrix metalloproteinases in the oral environment. Acta Odontologica Scandinavica, 2007;65(1):1-13). For additional information, contact A.R. Hannas, Endodontics and Dental Materials, Dept. of Operative Dentistry, Bauru School of Dentistry, Sao Paulo University, Brazil. The publisher's contact information for the journal Acta Odontologica Scandinavica is: Taylor & Francis as, Cort Adelersgt 17, PO Box 2562, Solli, 0202 Oslo, Norway. Keywords: Brazil, Matrix Metalloproteinase, Proteins, Proteomics. This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2007, Proteomics Weekly via NewsRx.com.
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