Researchers at Beaumont Hospital, Department of Neurology publish new data on amyotrophic lateral sclerosis genetics
2007 NOV 19 -- Research findings, 'Cognitive impairment in amyotrophic lateral sclerosis,' are discussed in a new report. According to a study from Dublin, Ireland, "Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that has sporadic and inherited forms. ALS is the most common neurodegenerative disorder of young and middle-aged adults, and few treatments are available." "Although the degeneration predominantly affects the motor system, cognitive and behavioural symptoms have been described for over a century, and there is evidence that ALS and frontotemporal dementia overlap clinically, radiologically, pathologically, and genetically. Cognitive decline in ALS is characterised by personality change, irritability, obsessions, poor insight, and pervasive deficits in frontal executive tests. This presentation is consistent with the changes to character, social conduct, and executive function in frontotemporal dementia. We highlight genetic, imaging, and neuropathological evidence that non-motor systems are affected in ALS and explain the importance of recent discoveries. We review studies of cognitive impairment in ALS and common neuropsychological test results. We also provide advice about clinical assessment of frontotemporal dysfunction in patients with ALS, and suggest future research," wrote J. Phukan and colleagues, Beaumont Hospital, Department of Neurology. The researchers concluded: "Understanding of cognitive impairment in ALS will improve care for patients and their families and provide valuable insights into the pathogenesis of neurodegeneration." Phukan and colleagues published the results of their research in Lancet Neurology (Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurology, 2007;6(11):994-1003). For additional information, contact J. Phukan, Beaumont Hospital, Dept. of Neurology, Dublin, Ireland. The publisher of the journal Lancet Neurology can be contacted at: Lancet Ltd., 84 Theobalds Rd., London WC1X 8RR, England. Keywords: Ireland, Dublin, Amyotrophic Lateral Sclerosis Genetics, Amyotrophic Lateral Sclerosis, Genetics, Motor Neuron Disease, Neurology. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.
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