Study data from Erasmus Medical Center, Department of Pathology update understanding of metabolism
2007 NOV 6 -- A new study, 'The role of cofactors in sex steroid action,' is now available. According to a study from Rotterdam, Netherlands, "Sex steroid signalling determines female and male sexual development and maintains the female and male phenotype in adults. Steroids carry out their function by activation of their cognate intracellular receptor, which is a ligand-dependent transcription factor." "Steroid receptors function by binding to specific structural elements in the regulatory regions of target genes and by recruitment of cofactors by protein-protein interaction. Cofactors might display enzymatic activities that modify histones and other proteins. Cofactors also include proteins that modulate the chromatin structure and protein complexes that function as bridging factors between the multi-protein complexes," wrote J. Trapman and colleagues, Erasmus Medical Center, Department of Pathology. The researchers concluded: "This review focuses mainly on the function of the androgen receptor and its cofactors and their role in androgen insensitivity syndrome." Trapman and colleagues published their study in Best Practice & Research Clinical Endocrinology & Metabolism (The role of cofactors in sex steroid action. Best Practice & Research Clinical Endocrinology & Metabolism, 2007;21(3):403-14). For more information, contact J. Trapman, Josephine Nefkens Institute, Dept. of Pathology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands. Publisher contact information for the journal Best Practice & Research Clinical Endocrinology & Metabolism is: Bailliere Tindall, 24-28 Oval Rd., London NW1 7DX, England. Keywords: Netherlands, Rotterdam, Clinical Endocrinology, Metabolism. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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