Our news journalists obtained a quote from the research from Federal University, "Patients with SCA have an imbalance between the production of reactive oxygen species and antioxidant capacity, generating oxidative stress. Nitric oxide (NO) is a potent vasodilator and may be involved in the mechanism of HbF induction. The aim of this study was to evaluate the impact of beta(S)-globin haplotypes in oxidative stress in patients with SCA. The study included 47 patients with SCA in steady state. The molecular diagnosis of SCA and characterization of the beta(S)-globin haplotype was performed by beta(S) chain polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Concentration of HbF was determined by high-performance liquid chromatography (HPLC). Serum levels of nitrite/nitrate (NOx) and malondialdehyde were determined by spectrophotometry. The most prevalent haplotype in the study population was Bantu. The Benin/n group presented significantly higher HbF and nitrite levels as compared to the Bantu/n group. Our results confirm data reported in the literature where the Benin and Bantu haplotypes are respectively correlated to high levels and decreased HbF."
According to the news editors, the research concluded: "In addition, haplotypes associated with high levels of HbF showed high levels of nitrite, demonstrating that as the HbF, serum levels of NOx may prove useful as a prognostic biomarker in patients with SCA."
For more information on this research see: Impact of beta(S)-Globin Haplotypes on Oxidative Stress in Patients with Sickle Cell Anemia in Steady State. Archives of Medical Research, 2012;43(7):536-540. Archives of Medical Research can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Archives of Medical Research - www.elsevier.com/wps/product/cws_home/601442)
The news correspondents report that additional information may be obtained from B.S. Carvalho-dos Santos, Univ Fed Ceara, Fortaleza, Ceara, Brazil.
Keywords for this news article include: Brazil, Globins, Genetics, Fortaleza, Hemeproteins, South America, Medical Research, Sickle Cell Anemia, Hematologic Diseases, Hemic and Lymphatic Diseases
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