Scientists at Erciyes University, Department of Cardiology describe research in atherosclerosis
2007 NOV 19 -- Scientists discuss in 'The relationship between Helicobacter pylori IgG titre and coronary atherosclerosis' new findings in atherosclerosis. "The role of Helicobacter pylori (HP) in the progression of atherosclerosis is controversial. We investigated the relation between HP IgG antibody titres and severity and intensity of coronary atherosclerosis and also clinical presentation of coronary artery disease (CAD) The patient group consisted of 353 patients with angiographically proven CAD, which contains 3 different subgroups: 163 patients with myocardial infarction (MI), 106 patients with unstable angina (USAP) and 84 patients with stable angina (SAP)," scientists writing in the journal Acta Cardiologica report. "Control group included 163 subjects with angiographically proven normal coronary arteries. Helicobacter pylori IgG antibody titres were measured by an enzyme immunoassay method in all patients. Gensini and Extent scores were used to evaluate the angiographic severity and extent of atherosclerosis. C-reactive protein levels were measured by Behring nephelometry system kits Seropositivity rates for HP were similar between groups (82.7% in the patient group and 86.6% in the control group (p >0.05)). Also HP-IgG levels were similar among the MI, USAP and SAP groups. No significant correlation was observed between CRP levels and HP-LgG level titres. There was no significant correlation between HP-IgG level (r=0.086, p=0.2) and Gensini score but a significant poor correlation was observed between HP-IgG level and Extent score (r=+ 0.156, p=0.03) Helicobacter pylori IgG titres do not play an important role in the presentation of CAD and do not increase systemic inflammatory response," wrote I. Ozdogru and colleagues, Erciyes University, Department of Cardiology. The researchers concluded: "However, Helicobacter pylori IgG antibody titres may be correlated with the extent of CAD." Ozdogru and colleagues published their study in Acta Cardiologica (The relationship between Helicobacter pylori IgG titre and coronary atherosclerosis. Acta Cardiologica, 2007;62(5):501-5). Additional information can be obtained by contacting I. Ozdogru, Erciyes University School of Medicine, Dept. of Cardiology, Kayseri, Turkey. The publisher of the journal Acta Cardiologica can be contacted at: Acta Cardiologica, Avenue Circulaire 138A, 1180 Brussels, Belgium. Keywords: Turkey, Kayseri, Angina, Atherosclerosis, Helicobacter. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.
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