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Research Results from Pomeranian Medical University Update Knowledge of AIDS/HIV Research

2013 JAN 21 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Fresh data on AIDS/HIV Research are presented in a new report. According to news reporting from Szczecin, Poland, by NewsRx journalists, research stated, "Il28B single nucleotide polymorphisms were found to influence interferon lambda expression, resulting in changes in hepatitis C virus (HCV)-RNA serum levels as well as the HIV-RNA set point prior to combined antiretroviral therapy (cART). To date, there is limited information on the influence of this polymorphism on survival in HIV-infected, treatment-naive, and antiretroviral-treated patients."

The news correspondents obtained a quote from the research from Pomeranian Medical University, "Longitudinal data from 484 patients diagnosed with HIV infection (including 406 on cART) were analyzed to investigate the association between Il28B rs 1979860 variants and all-cause mortality. Kaplan-Meyer and Cox models were used to calculate the hazard ratio associated with IL28B genotypes predictive of a greater likelihood of survival for patients prior to the introduction of cART and for patients on cART. The IL28B genotype frequencies were 41.7% (n = 202) for CC, 46.5% (n = 225) for CT, and 11.7% (n = 57) for TT patients. The CC variant was associated with higher mortality (46 cases, 22.8%) compared to other genotypes [n = 31 (13.8%) and n = 7 (12.3%) for CT and TT, respectively, p = 0.02]. IL28 genotypes did not influence the survival probability prior to treatment initiation (HR 1.04, 95% CI: 0.84-1.24, p = 0.68). In antiretroviral-treated patients, after adjustment for gender, baseline CD4 count, CDC category at HIV diagnosis, and age (multivariate HR 1.75, 95% CI: 1.20-2.30, p = 0.047), the CC genotype was associated with a decreased probability of survival when compared to the non-CC genotype (univariate HR 1.8, 95% CI: 1.28-2.34, p = 0.029). IL28B rs12979860 genotypes influence mortality risk in HIV-infected, antiretroviral-treated patients."

According to the news reporters, the research concluded: "The effect may be related to higher baseline plasma HIV viremia and possibly altered immune reconstitution associated with interferon lambda expression."

For more information on this research see: IL28B CC Genotype Is Associated with Higher All-Cause Mortality in Antiretroviral-Treated HIV-Infected Patients. Aids Research and Human Retroviruses, 2012;28(12):1640-1646. Aids Research and Human Retroviruses can be contacted at: Mary Ann Liebert Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Aids Research and Human Retroviruses - www.liebertpub.com/overview/aids-research-and-human-retroviruses/2/)

Our news journalists report that additional information may be obtained by contacting M. Parczewski, Pomeranian Medical University, Dept. of Infect Dis & Hepatol, PL-71455 Szczecin, Poland.

Keywords for this news article include: Antiretrovirals, Drugs, Poland, Europe, Therapy, Szczecin, Genetics, HIV/AIDS, RNA Viruses, Retroviridae, HIV Infections, AIDS/HIV Research, Vertebrate Viruses, Primate Lentiviruses, Viral Sexually Transmitted Diseases

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