Study findings from Wake Forest University, Institute for Regenerative Medicine broaden understanding of tissue engineering
2007 NOV 21 -- New research, 'Oxygen producing biomaterials for tissue regeneration,' is the subject of a report. "A limiting factor in regenerating large organs and healing large wounds completely is the inability to provide oxygen to the affected areas for vascularization and healing to occur. An oxygen rich compound of sodium percarbonate was incorporated into films of Poly(D,L-lactide-co-glycolide) (PLGA) and used for in situ production of oxygen," scientists writing in the journal Biomaterials report. "Oxygen release could be observed from the film over a period of 24 h. When the oxygen producing biomaterials were placed in contact with ischemic tissue in a mouse model, decreased tissue necrosis and cellular apoptosis was observed," wrote B.S. Harrison and colleagues, Wake Forest University, Institute for Regenerative Medicine. The researchers concluded: "This indicates that improved tissue viability could be maintained for several days using oxygen producing biomaterials." Harrison and colleagues published their study in Biomaterials (Oxygen producing biomaterials for tissue regeneration. Biomaterials, 2007;28(31):4628-34). Additional information can be obtained by contacting B.S. Harrison, Wake Forest Institute for Regenerative Medicine, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC 27157 USA.. The publisher of the journal Biomaterials can be contacted at: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. Keywords: United States, Winston-Salem, Tissue Engineering, Tissue Regeneration. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2007, Biotech Week via NewsRx.com.
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