New apoptosis cell biology findings from Medical University of Vienna, Institute of Cancer Research published
2007 NOV 21 -- Researchers detail in 'Oncogenic c-H-ras deregulates survivin expression: an improvement for survival,' new data in apoptosis. "Survivin protein accomplishes two basic functions: cell cycle regulation and control of apoptosis," scientists in Vienna, Austria report. "It is only expressed in G2/M phase and it influences rescue pathways in apoptosis-induced cells. Overexpression of constitutive active c-H-ras in HeLa, or induction of c-H-ras in a stable HeLaDiR cell line, led to sustained survivin expression in all cell cycle phases and even protected cells from drug induced apoptosis. siRNA-mediated silencing of survivin reversed this protection," wrote K.W. Sommer and colleagues, Medical University of Vienna, Institute of Cancer Research. The researchers concluded: "Here we link the anti-apoptotic property of survivin to its cell cycle (in)dependent regulation via the activity of oncogenic c-H-ras." Sommer and colleagues published their study in FEBS Letters (Oncogenic c-H-ras deregulates survivin expression: an improvement for survival. FEBS Letters, 2007;581(25):4921-6). For more information, contact K.W. Sommer, Medical University of Vienna, Medical University of Vienna, Division Institute of Cancer Research, Borschkegasse 8a, 1090 Vienna, Austria. Publisher contact information for the journal FEBS Letters is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands. Keywords: Austria, Vienna, Apoptosis Cell Biology, Apoptosis. This article was prepared by Biotech Week editors from staff and other reports. Copyright 2007, Biotech Week via NewsRx.com.
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