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Investigators from Wake Forest Baptist Medical Center Have Published New Data on Neurology

2012 NOV 5 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on Neurology have been published. According to news reporting from Winston Salem, North Carolina, by NewsRx journalists, research stated, "It has been well established that Gamma Knife radiosurgery (GKS) is an effective treatment for brain arteriovenous malformations (AVMs). To evaluate complete obliteration rates for magnetic resonance imaging (MRI)-based GKS treatment planning performed with and without angiography and to conduct a preliminary assessment of the utility of using pulsed arterial spin labeling (PASL) magnetic resonance (MR) perfusion imaging to confirm complete obliteration."

The news correspondents obtained a quote from the research from Wake Forest Baptist Medical Center, "Forty-six patients were identified who had undergone GKS without embolization with a minimum follow-up of 2 years. One group was planned with integrated stereotactic angiography and MR (spoiled gradient recalled) images obtained on the day of GKS. A second technique avoided the risk of arteriography by using only axial MR images. Beginning in 2007, PASL MR perfusion imaging was routinely performed as a portion of the follow-up MRI to assess the restoration of normal blood flow of the nidus and surrounding area. The overall obliteration rate for the angiography/MRI group was 88.0% (29 of 33). Patients in the MRI-only group had an obliteration rate of 61.5% (8 of 13), with P = .092 with the Fisher exact test, which is not statistically significant. A Kaplan-Meier analysis was also not statistically significant (log rank test, P = .474). Four of 9 patients with incomplete obliteration on angiography also had shown residual abnormal blood flow on PASL imaging. This retrospective analysis shows that treatment planning technique used in GKS does not play a role in the eventual obliteration of treated AVMs."

According to the news reporters, the research concluded: "PASL may have potential in the evaluation of AVM obliteration."

For more information on this research see: Retrospective Analysis of Imaging Techniques for Treatment Planning and Monitoring of Obliteration for Gamma Knife Treatment of Cerebral Arteriovenous Malformation. Neurosurgery, 2012;71(4):893-899. Neurosurgery can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins - www.lww.com; Neurosurgery - journals.lww.com/neurosurgery/pages/default.aspx)

Our news journalists report that additional information may be obtained by contacting K. Amponsah, Wake Forest Baptist Med Center, Div Public Hlth Sci, Winston Salem, NC, United States.

Keywords for this news article include: Neurology, Winston Salem, United States, North Carolina, Vascular Malformations, Cardiovascular Diseases, Congenital Abnormalities, North and Central America, Arteriovenous Malformations, Cardiovascular Abnormalities

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2012, NewsRx LLC