The news reporters obtained a quote from the research from Lung and Blood Institute, "Increased expression of ABCA1 was not observed in resident peritoneal macrophages. ApoA-I-mediated cholesterol efflux from aortic EC was 2.6-fold higher (p <0.0001) for cells from transgenic versus control mice. On normal chow diet, Tie2 hABCA1 transgenic mice had a 25% (p <0.0001) increase in HDL-cholesterol (HDL-C) and more than a 2-fold increase of eNOS mRNA in the aorta (p <0.04). After 6 months on a high-fat, high-cholesterol (HFHC) diet, transgenic mice compared with controls had a 40% increase in plasma HDL-C (p <0.003) and close to 40% decrease in aortic lesions (p <0.02). Aortas from HFHC-fed transgenic mice also showed gene expression changes consistent with decreased inflammation and apoptosis. Beneficial effects of the ABCA1 transgene on HDL-C levels or on atherosclerosis were absent when the transgene was transferred onto ApoE or Abca1 knockout mice."
According to the news reporters, the research concluded: "In summary, expression of hABCA1 in EC appears to play a role in decreasing diet-induced atherosclerosis in mice and is associated with increased plasma HDL-C levels and beneficial gene expression changes in EC."
For more information on this research see: Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis. Journal of Lipid Research, 2012;53(1):158-67. Journal of Lipid Research can be contacted at: Amer Soc Biochemistry Molecular Biology Inc, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA. (American Society for Biochemistry and Molecular Biology - www.asbmb.org; Journal of Lipid Research - www.jlr.org/)
Our news correspondents report that additional information may be obtained by contacting B.L. Vaisman, Cardiovascular-Pulmonary Branch, National Heart, Lung and Blood Institute, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
The publisher of the Journal of Lipid Research can be contacted at: Amer Soc Biochemistry Molecular Biology Inc, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA.
Keywords for this news article include: Lipids, Bethesda, Maryland, United States, Atherosclerosis, HDL Cholesterol, Arteriosclerosis, HDL Lipoproteins, Cardiovascular Diseases, North and Central America, Arterial Occlusive Diseases.
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