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Research on chronic kidney failure reported by scientists at Drexel University
2009 OCT 5 - (NewsRx.com) -- "The purpose of the present study was to examine the effect of hemodialysis procedures on the hemoconcentration status of end-stage renal disease (ESRD) patients. We measured whole blood viscosity (WBV) of 30 ESRD patients using a scanning-capillary-tube viscometer before and after hemodialysis," scientists in the United States report. "The blood sample size required for WBV measurements was approximately 3 mL. Pre-dialysis specimens for viscosity measurements were obtained via the fistula needle or Perma catheter prior to initiating hemodialysis, and post-dialysis specimens were drawn from the arterial sample port of the hemodialysis line 3.5 hours after initiation of dialysis treatment. Changes in WBV were measured at high and low shear rates: 80% of patients showed an increased high shear viscosity, whereas 73% of patients demonstrated an increased low shear viscosity. The actual percentage increase in WBV observed after hemodialysis at high and low shear rate ranges varied broadly in the 30 patients. The observed increase in the WBV of ESRD patients over hemodialysis procedures indicates that a segment of patients experience increased flow resistance, particularly at the microcirculatory level. In addition, for the segment of patients experiencing marked increases in WBV during hemodialysis, the vessel wall at the dialysis fistula is exposed to blood with a higher viscosity than at the beginning of the process," wrote S. Vaisman and colleagues, Drexel University. The researchers concluded: "The higher blood viscosity at the dialysis fistula is directly related to increased kinetic force and shear stress on the vessel wall, which may be playing a role in increasing the risk of stenosis. (Int J Artif Organs 2009; 32:329-35)'." Vaisman and colleagues published their study in International Journal of Artificial Organs (Effect of hemodialysis on whole blood viscosity. International Journal of Artificial Organs, 2009;32(6):329-335). For more information, contact Y.I. Cho, Drexel University, Dept. of Mech Engineering & Mech, 3141 Chestnut St., Philadelphia, PA 19104, USA. Publisher contact information for the International Journal of Artificial Organs is: Wichtig Editore, 72, 74 Via Friuli, 20135 Milan, Italy. Keywords: United States, Philadelphia, Artificial Organs, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Chronic Kidney Failure, Hemodialysis, Nephrology, Renal Dialysis, Renal Disease, Drexel University. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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