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Research on pulmonary hypertension reported by scientists at Chang Gung Memorial Hospital, Department of Cardiac Surgery
2009 JUL 13 - (NewsRx.com) -- Data detailed in 'Extracorporeal life support: a simple and effective weapon for postcardiotomy right ventricular failure' have been presented. According to a study from Taiwan, "Postcardiotomy right ventricular (RV) failure develops during the perioperative period following pulmonary hypertensive crisis or acute myocardial infarction. This study reports our institutional experience in treating these patients with extracorporeal life support (ECLS)." "Between June 2002 and July 2005, 46 adults were treated with ECLS for postcardiotomy shock. Acute RV failure was the cause of support in 14 (30%). Patient mean age was 55.7 ±15.4 years. Cardiac pathologies were valvular (n=7), coronary (n=1), combined coronary and valvular disease (n=2), complex congenital heart (n=2), aortic aneurysm (n=1), and cardiomyopathy post heart transplant (n=1). The triggers of RV failure were pulmonary hypertension (n=6), RV infarction (n=4), and not defined (n=4). Patients were supported on ECLS for a mean duration of 71 ±52 h (range, 10-183 h). Major complications included acute renal failure requiring hemodialysis (n=4), reexploration for bleeding (n=2), and acute subdural hematoma (n=1). Nine (64%) patients were successfully weaned from ECLS, and seven (50%) survived to discharge. Preexisting pulmonary hypertension had a favorable tendency for weaning, and acute renal failure requiring hemodialysis correlated with in-hospital mortality. ECLS is beneficial for treating postcardiotomy RV failure when conventional therapy is exhausted," wrote K.S. Liu and colleagues, Chang Gung Memorial Hospital, Department of Cardiac Surgery. The researchers concluded: "As it can be deployed rapidly and does not require resternotomy for weaning, ECLS could be regarded as the first choice of mechanical support for postcardiotomy RV failure." Liu and colleagues published their study in Artificial Organs (Extracorporeal life support: a simple and effective weapon for postcardiotomy right ventricular failure. Artificial Organs, 2009;33(7):504-8). For more information, contact K.S. Liu, Chang Gung Memorial Hospital, Dept. of Cardiac Surgery, Taoyuan Hsien, Taiwan. Publisher contact information for the journal Artificial Organs is: Blackwell Publishing Inc., 350 Main St., Malden, MA 02148, USA. Keywords: Taiwan, Aortic Aneurysm, Artificial Organs, Bioengineering, Biomedical Engineering, Biomedicine, Biotechnology, Cardiac Surgery, Cardiology, Cardiomyopathies, Cardiomyopathy, Heart Attack, Heart Transplant, Myocardial Infarction, Organ Transplant, Pulmonary Hypertension, Valvular Disease. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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