Researchers at Kuopio University target pediatric in children
2007 NOV 20 -- Investigators publish new data in the report 'Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis.' According to recent research from Kuopio, Finland, "Atopic infants hospitalized for wheezing not caused by respiratory syncytial virus (RSV) carry the highest risk for later asthma. In the present paper, early risk factors for later lung function abnormalities and for bronchial hyper-responsiveness (BHR) were evaluated in 81 children, hospitalized for bronchiolitis in infancy, at the median age of 12.3 years The basic data, including data on atopy in children and viral aetiology of bronchiolitis, had been collected on entry to the study at less than 2 years of age." "Lung function was studied by flow-volume spirometry (FVS), and BHR by methacholine and exercise challenge tests 11.4 years after hospitalization during infancy RSV aetiology of bronchiolitis was associated with reduced forced vital capacity (FVC; 93.65% of predicted ±11.05 vs. 99.57%±12.59, p=0.009). Early sensitization to inhalant allergens (OR 12.59, 95% CI 2.30-68.77) and maternal smoking during pregnancy (OR 4.58, 95% CI 1.28-16.39) were associated with BHR to exercise, and early atopic dermatitis (OR 3.48, 95% CI 1.09-11.10) was associated with BHR to methacholine RSV bronchiolitis was associated with a restrictive pattern of lung function," wrote M.K. Hyv-rinen and colleagues, Kuopio University. The researchers concluded: "Early atopy and maternal smoking during pregnancy may play a role in the development and persistence of BHR." Hyv-rinen and colleagues published their study in Acta Paediatrica (Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis. Acta Paediatrica, 2007;96(10):1464-9). For additional information, contact M.K. Hyv-rinen, Kuopio University and Kuopio University Hospital, Dept. of Paediatrics, Kuopio, Finland. Publisher contact information for the journal Acta Paediatrica is: Taylor & Francis as, Cort Adelersgt 17, PO Box 2562, Solli, 0202 Oslo, Norway. Keywords: Finland, Kuopio, Life Sciences, Pediatrics, Pulmonology, Bronchiolitis. This article was prepared by Disease Prevention Week editors from staff and other reports. Copyright 2007, Disease Prevention Week via NewsRx.com.
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