New findings reported from Stanford University, Department of Pediatrics describe advances in autoimmune disease
2007 NOV 20 -- A report, 'Posttranslational regulation of I-Ed by affinity for CLIP,' is newly published data in The Journal of Immunology. "Several MHC class II alleles linked with autoimmune diseases form unusually low stability complexes with CLIP, leading us to hypothesize that this is an important feature contributing to autoimmune pathogenesis. To investigate cellular consequences of altering class II/CLIP affinity, we evaluated invariant chain (Ii) mutants with varying CLIP affinity for a mouse class II allele, I-E(d), which has low affinity for wild-type CLIP and is associated with a mouse model of spontaneous, autoimmune joint inflammation," scientists in the United States report. "Increasing CLIP affinity for I-E(d) resulted in increased cell surface and total cellular abundance and half-life of I-E(d). This reveals a post-endoplasmic reticulum chaperoning capacity of Ii via its CLIP peptides. Quantitative effects on I-E(d) were less pronounced in DM-expressing cells, suggesting complementary chaperoning effects mediated by Ii and DM, and implying that the impact of allelic variation in CLIP affinity on immune responses will be highest in cells with limited DM activity," wrote C.H. Rinderknecht and colleagues, Stanford University, Department of Pediatrics. The researchers concluded: "Differences in the ability of cell lines expressing wild-type or high-CLIP-affinity mutant Ii to present Ag to T cells suggest a model in which increased CLIP affinity for class II serves to restrict peptide loading to DM-containing compartments, ensuring proper editing of antigenic peptides." Rinderknecht and colleagues published their study in the Journal of Immunology (Posttranslational regulation of I-Ed by affinity for CLIP. Journal of Immunology, 2007;179(9):5907-15). For additional information, contact C.H. Rinderknecht, Program in Immunology, Dept. of Pediatrics, Stanford University, Stanford, CA 94305 USA.. The publisher's contact information for the Journal of Immunology is: American Association Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: United States, Stanford, Autoimmune Disease, Autoimmune Disorder, Immunology. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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