New autoimmune disease study findings have been reported from University of Oxford
2007 NOV 20 -- Scientists discuss in 'MyD88-dependent autoimmune disease in Lyn-deficient mice' new findings in autoimmune disease. "Recent evidence suggests that systemic autoimmune disease depends on signals from TLR ligands, but little is known about how TLR-dependent pathways lead to the loss of self tolerance in vivo. To address this, we have examined the role of TLR signaling in Lyn-deficient mice, which develop an autoimmune disease similar to SLE," scientists writing in the European Journal of Immunology report. "We found that absence of the TLR signaling adaptor molecule MyD88 suppresses plasma cell differentiation of switched and unswitched B cells, and prevents the generation of antinuclear IgG antibodies and glomerulonephritis. In mixed chimeras the increased IgM and IgG antibody secretion in Lyn-deficient mice is at least partially due to B cell-independent effects of Lyn. We now show that MyD88 deficiency blocks the expansion and activation of DC in which Lyn is also normally expressed, and prevents the hypersecretion of proinflammatory cytokines IL-6 and IL-12 by Lyn-deficient DC," wrote K.L. Silver and colleagues, University of Oxford. The researchers concluded: "These findings further highlight the important role of TLR-dependent signals in both lymphocyte activation and autoimmune pathogenesis." Silver and colleagues published their study in European Journal of Immunology (MyD88-dependent autoimmune disease in Lyn-deficient mice. European Journal of Immunology, 2007;37(10):2734-43). Additional information can be obtained by contacting K.L. Silver, University of Oxford, Henry Wellcome Building of Molecular Physiology, Oxford, UK. The publisher of the European Journal of Immunology can be contacted at: Wiley-V C H Verlag GmbH, PO Box 10 11 61, D-69451 Weinheim, Germany. Keywords: United Kingdom, Oxford, Autoimmune Disease, Autoimmune Disorder, Immunology. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
|
