Researchers from University of California discuss findings in biomechanics
2007 NOV 13 -- Data detailed in 'Novel biomechanical quantification methodology for lumbar intraforaminal spinal nerve adhesion in a laminectomy and disc injury rat model' have been presented. "Spinal nerve fibrosis following injury or surgical intervention may play an important role in the pathophysiology of chronic back pain. In this current study, we demonstrate the role of biomechanical quantification of lumbar intraforaminal spinal nerve adhesion and tethering in the analysis of the post-laminectomy condition and describe a direct methodology to make this measurement," investigators in the United States report. "Twenty age-matched Sprague-Dawley male rats were divided into operative and non-operative (control) groups. Operative animals underwent a bilateral L5-L6 laminectomy with right-side L5-6 disc injury, a post-laminectomy pain model previously published by this lab. At eight weeks, animals were sacrificed and the strength of adhesion of the L5 intraforaminal spinal nerve to surrounding structures was quantified using a novel biomechanical methodology. Operative animals were found to have a significantly greater load to displace the intact right L5 spinal nerve through the intervertebral foramen when compared to control animals," wrote V.A. Kulkarni and colleagues, University of California. The researchers concluded: "The findings show that the post-laminectomy condition creates quantifiable fibrosis of the spinal nerve to surrounding structures and supports the conclusion that this fibrosis may play a role in the post-laminectomy pain syndrome." Kulkarni and colleagues published their study in the Journal of Neuroscience Methods (Novel biomechanical quantification methodology for lumbar intraforaminal spinal nerve adhesion in a laminectomy and disc injury rat model. Journal of Neuroscience Methods, 2007;166(1):20-3). For additional information, contact V.A. Kulkarni, Veterans Affairs Medical Center and University of California, Dept. of Orthopaedic Surgery, San Diego, CA USA.. The publisher of the Journal of Neuroscience Methods can be contacted at: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands. Keywords: United States, San Diego, Bioengineering, Biomechanics, Laminectomy, Neuroscience, Surgery. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
|
