Studies from Marmara University, Department of Internal Medicine reveal new findings on Behcet disease immunology
2007 NOV 12 -- Researchers detail in 'PTPN22 gene polymorphism in Beh(gamma)et's disease,' new data in Behcet disease. According to recent research published in the journal Tissue Antigens, "A functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the protein tyrosine phosphatase has been reported to be associated with autoimmune disorders such as rheumatoid arthritis, systemic lupus erythematosus and type I diabetes. PTPN22 R620W polymorphism has a wide variation of allelic frequencies among different populations." "This polymorphism is investigated in Turkish patients with Beh(gamma)et's disease (BD), a systemic vasculitis with immune activation. DNA samples from 134 patients with BD and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism method for the SNP (rs2476601, A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with XcmI enzyme. The frequency of heterozygous genotype (AG) was 5.1% (9/177) in control group, whereas polymorphic allele was not present in the whole BD group (p=0.012, OR 0.65, 95% confidence interval 0.0-1.1)," wrote N. Sahin and colleagues, Marmara University, Department of Internal Medicine. The researchers concluded: "Both the lower prevalence in the general population and the absence in BD show the limited role of PTPN22 polymorphism in the pathogenesis of autoimmunity in Turkey." Sahin and colleagues published their study in Tissue Antigens (PTPN22 gene polymorphism in Beh(gamma)et's disease. Tissue Antigens, 2007;70(5):432-4). For additional information, contact N. Sahin, Dept. of Internal Medicine, Division of Rheumatology, Marmara University Medical School, Istanbul, Turkey. The publisher's contact information for the journal Tissue Antigens is: Blackwell Munksgaard, 35 Norre Sogade, PO Box 2148, DK-1016 Copenhagen, Denmark. Keywords: Turkey, Istanbul, Behcet Disease Immunology, Arthritis, Autoimmune Disease, Autoimmune Disorders, Behcet Disease, Behcet Syndrome, Immunology, Insulin Dependent Diabetes Mellitus, Phosphatase, Rheumatoid Arthritis, Rheumatology, Systemic Lupus Erythematosus, Type 1 Diabetes. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.
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