Bioelectromagnetics
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New findings from M.G. Moisescu and co-authors describe advances in endocytosis
2009 MAY 26 - (NewsRx.com) -- According to recent research from Villejuif, France, "We report new data regarding the molecular mechanisms of GSM-induced increase of cell endocytosis rate. Even though endocytosis represents an important physical and biological event for cell physiology, studies on modulated electromagnetic fields (EMF) effects on this process are scarce." "In a previous article, we showed that fluid phase endocytosis rate increases when cultured cells are exposed to 900 MHz EMF similar to mobile phones' modulated GSM signals (217 Hz repetition frequency, 576 mu s pulse width) and to electric pulses similar to the GSM electrical component. Trying to distinguish the mechanisms sustaining this endocytosis stimulation, we exposed murine melanoma cells to Lucifer Yellow (LY) or to GSM-EMF/electric pulses in the presence of drugs inhibiting the clathrin- or the caveolin-dependent endocytosis. Experiments were performed at a specific absorption rate (SAR) of 3.2 W/kg in a wire patch cell under homogeneously distributed EMF field and controlled temperature (in the range of 28.5-29.5 degrees C). Thus, the observed increase in LYuptake was not a thermal effect. Chlorpromazine and ethanol, but not Filipin, inhibited this increase," wrote M.G. Moisescu and colleagues. The researchers concluded: "Therefore, the clathrin-dependent endocytosis is stimulated by the GSM-EMF, suggesting that the cellular mechanism affected by the modulated EMF involves vesicles that detach from the cell membrane, mainly clathrin-coated vesicles. Bioelectromagnetics 30:222-230, 2009." Moisescu and colleagues published their study in Bioelectromagnetics (900 MHz Modulated Electromagnetic Fields Accelerate the Clathrin-Mediated Endocytosis Pathway. Bioelectromagnetics, 2009;30(3):222-230). For additional information, contact L.M. Mir, Institute Gustave Roussy, CNRS, UMR Vectorol & Gene Transfer 8121, 39 Rue Camille Desmoulins, F-94805 Villejuif, France. Publisher contact information for the journal Bioelectromagnetics is: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA. Keywords: France, Villejuif, Bioelectromagnetics, Endocytosis, Melanoma, Physiology. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2009, Life Science Weekly via NewsRx.com.
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