Biological Cybernetics
Return to Library
Data on Parkinson disease reported by researchers at Technical University
2009 JUN 22 - (NewsRx.com) -- According to recent research from Murcia, Spain, "In this paper, we present a neural network model of the interactions between cortex and the basal ganglia during prehensile movements. Computational neuroscience methods are used to explore the hypothesis that the altered kinematic patterns observed in Parkinson's disease patients performing prehensile movements is mainly due to an altered neuronal activity located in the networks of cholinergic (ACh) interneurons of the striatum." "These striatal cells, under a strong influence of the dopaminergic system, significantly contribute to the neural processing within the striatum and in the cortico-basal ganglia loops. In order to test this hypothesis, a large-scale model of neural interactions in the basal ganglia has been integrated with previous models accounting for the cortical organization of goal directed reaching and grasping movements in normal and perturbed conditions," wrote J. Molinavilaplana and colleagues, Technical University. The researchers concluded: "We carry out a discussion of the model hypothesis validation by providing a control engineering analysis and by comparing results of real experiments with our simulation results in conditions resembling these original experiments." Molinavilaplana and colleagues published their study in Biological Cybernetics (A model for altered neural network dynamics related to prehension movements in Parkinson disease. Biological Cybernetics, 2009;100(4):271-287). For additional information, contact J. Molinavilaplana, Technical University Cartagena, Dept. of Systems Engineering & Automat, Campus Muralla del Mar, C Doctor Fleming S-N, Murcia 30202, Spain. Publisher contact information for the journal Biological Cybernetics is: Springer, 233 Spring St., New York, NY 10013, USA. Keywords: Spain, Murcia, Biological Cybernetics, Central Nervous System Disease, Computational Neuroscience, Parkinson Disease, Technical University. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
|
