Research conducted at University of Bonn, Institute of Human Genetics has provided new information about bipolar disorder genetics
2007 NOV 19 -- Current study results from the report, 'The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q,' have been published. According to recent research published in the The American Journal of Human Genetics, "We present the first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder (BPAD), using a large linkage data set (52 families of European descent; 448 participants and 259 affected individuals). Our results provide the strongest interaction evidence between BPAD genes on chromosomes 2q22-q24 and 6q23-q24, which was observed symmetrically in both directions (nonparametric LOD [NPL] scores of 7.55 on 2q and 7.63 on 6q; p<.0001 and p=.0001, respectively, after a genomewide permutation procedure)." "The second-best BPAD interaction evidence was observed between chromosomes 2q22-q24 and 15q26. Here, we also observed a symmetrical interaction (NPL scores of 6.26 on 2q and 4.59 on 15q; p=.0057 and .0022, respectively). We covered the implicated regions by genotyping additional marker sets and performed a detailed interaction linkage analysis, which narrowed the susceptibility intervals. Although the heterogeneity analysis produced less impressive results (highest NPL score of 3.32) and a less consistent picture, we achieved evidence of locus heterogeneity at chromosomes 2q, 6p, 11p, 13q, and 22q, which was supported by adjacent markers within each region and by previously reported BPAD linkage findings," wrote Jamra R. Abou and colleagues, University of Bonn, Institute of Human Genetics. The researchers concluded: "Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies." Abou and colleagues published their study in The American Journal of Human Genetics (The first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder: strong evidence of epistatic effects between loci on chromosomes 2q and 6q. The American Journal of Human Genetics, 2007;81(5):974-86). For additional information, contact R. Abou Jamra, University of Bonn, Institute of Human Genetics, Bonn, Germany. The publisher's contact information for the The American Journal of Human Genetics is: University Chicago Press, 1427 E 60th St., Chicago, IL 60637-2954, USA. Keywords: Germany, Bonn, Bipolar Disorder Genetics, Bipolar Disorder, Manic-Depressive Illness, Psychiatry. This article was prepared by Mental Health Weekly Digest editors from staff and other reports. Copyright 2007, Mental Health Weekly Digest via NewsRx.com.
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