Study findings on personality disorders therapy are outlined in reports from H. Steiger and colleagues
2007 OCT 22 -- Current study results from the report, 'The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes,' have been published. "' Low-function alleles of the serotonin transporter promoter polymorphism (5HTTLPR) have been linked to various psychopathological entities, especially in individuals exposed to prior stressors. In women with bulimic syndromes, we explored associations with personality pathology of 5HTTLPR and prior sexual or physical maltreatment," scientists in Canada report. "Ninety-two women with bulimic syndromes were genotyped for 5HTTLPR short (S) and long (L(G) and L(A)) alleles and were then assessed for eating symptoms, dimensional personality disturbances, history of sexual or physical abuse and borderline personality disorder (BPD). With a classification based on a biallelic model of 5HTTLPR (i.e., presence or absence of at least 1 S-allele copy), multiple regression analyses indicated significant proportions of variance in stimulus seeking and insecure attachment to be explained by abuse x genotype interaction effects, with greater psychopathology always occurring in S-allele carriers who had been abused. Likewise, a logistic regression analysis linked BPD to significant main effects of genotype and abuse. Analyses that aggregated carriers according to a triallelic model of 5HTTLPR (i.e., presence or absence of at least 1 copy of a presumably low-function S or LG allele) produced similar patterns but no statistically significant effects. Traits such as sensation seeking and insecure attachment are, on average, elevated in 5HTTLPR S-allele carriers with bulimic syndromes who report prior physical or sexual maltreatment," wrote H. Steiger and colleagues, . The researchers concluded: "These results add to the literature associating pronounced psychopathological manifestations, with conjoint effects of stress and the 5HTTLPR polymorphism." Steiger and colleagues published their study in the Journal of Psychiatry and Neuroscience (The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes. Journal of Psychiatry and Neuroscience, 2007;32(5):354-62). For additional information, contact H. Steiger, Douglas Hospital, Eating Disorders Program, 6875 LaSalle Blvd., Montreal QC H4H 1R3, Canada. The publisher's contact information for the Journal of Psychiatry and Neuroscience is: Canadian Medical Association, 1867 Alta Vista Dr., Ottawa, Ontario K1G 3Y6, Canada. Keywords: Canada, Personality Disorders Therapy, Mental Health, Neuroscience, Psychiatry. This article was prepared by Mental Health Weekly Digest editors from staff and other reports. Copyright 2007, Mental Health Weekly Digest via NewsRx.com.
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