New long-qt syndrome physiology study findings have been reported by C. Antzelevitch and colleagues
2007 NOV 12 -- Researchers detail in 'Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes,' new data in long-qt syndrome. According to recent research from the United States, "This review examines the role of spatial electrical heterogeneity within the ventricular myocardium on the function of the heart in health and disease. The cellular basis for transmural dispersion of repolarization (TDR) is reviewed, and the hypothesis that amplification of spatial dispersion of repolarization underlies the development of life-threatening ventricular arrhythmias associated with inherited ion channelopathies is evaluated." "The role of TDR in long QT, short QT, and Brugada syndromes, as well as catecholaminergic polymorphic ventricular tachycardia (VT), is critically examined. In long QT syndrome, amplification of TDR is often secondary to preferential prolongation of the action potential duration (APD) of M cells; in Brugada syndrome, however, it is thought to be due to selective abbreviation of the APD of the right ventricular epicardium. Preferential abbreviation of APD of the endocardium or epicardium appears to be responsible for the amplification of TDR in short QT syndrome," wrote C. Antzelevitch and colleagues, . The researchers concluded: "In catecholaminergic polymorphic VT, reversal of the direction of activation of the ventricular wall is responsible for the increase in TDRlong QT, short QT, Brugada, and catecholaminergic polymorphic VT syndromes are pathologies with very different phenotypes and etiologies, but they share a common final pathway in causing sudden cardiac death." Antzelevitch and colleagues published their study in American Journal of Physiology - Heart and Circulatory Physiology (Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. American Journal of Physiology - Heart and Circulatory Physiology, 2007;293(4):H2024-38). For additional information, contact C. Antzelevitch, Masonic Medical Research Laboratory, 2150 Bleecker St., Utica, NY 13501-1787 USA.. Publisher contact information for the American Journal of Physiology - Heart and Circulatory Physiology is: American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA. Keywords: United States, Utica, Long-QT Syndrome Physiology, Brugada Syndrome, Cardiology, Catecholamin, Long QT Syndrome, Long-QT Syndrome, Neurology, Physiology, Sudden Cardiac Death, Ventricular Tachycardia. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2007, Pain & Central Nervous System Week via NewsRx.com.
|
