Researchers from University Hospital, Department of Cardiology detail new studies and findings in the area of ventricular fibrillation genetics
2007 NOV 5 -- New research, 'Brugada syndrome unmasked by accidental inhalation of gasoline vapors,' is the subject of a report. "Loss-of-function mutations in the gene SCN5A can cause Brugada syndrome (BrS), which is an inherited form of idiopathic ventricular fibrillation. We report the case of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline vapors," investigators in Zagreb, Croatia report. "His electrocardiogram (ECG) showed a typical type-1 BrS pattern that persisted after the acute event. Genetic investigations allowed the identification of a novel SCN5A mutation leading to a frame-shift and early termination of the channel protein. Biochemical and cellular electrophysiology experiments confirmed the loss-of-function of the mutant allele," wrote D. Kranjcec and colleagues, University Hospital, Department of Cardiology. The researchers concluded: "The patient was implanted with a cardioverter/defibrillator." Kranjcec and colleagues published their study in PACE - Pacing and Clinical Electrophysiology (Brugada syndrome unmasked by accidental inhalation of gasoline vapors. PACE - Pacing and Clinical Electrophysiology, 2007;30(10):1294-8). For additional information, contact D. Kranjcec, University Hospital Dubrava, Dept. of Cardiology, Zagreb, Croatia. The publisher of the journal PACE - Pacing and Clinical Electrophysiology can be contacted at: Blackwell Futura Publishing, Inc., 350 Main Street, Malden, MA 01248-5018, USA. Keywords: Croatia, Zagreb, Ventricular Fibrillation Genetics, Brugada Syndrome, Cardiology, Electrophysiology, Ventricular Fibrillation. This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2007, Cardiovascular Week via NewsRx.com.
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