New angiogenesis study findings recently were published by investigators at Cancer Research UK London Research Institute
2007 NOV 12 -- A report, 'Regulation of vascular morphogenesis by Notch signaling,' is newly published data in Genes & Development. "The Notch pathway is a versatile regulator of cell fate specification, growth, differentiation, and patterning processes in metazoan organisms. In the vertebrate cardiovascular system, multiple Notch family receptors and several of their Jagged and Delta-like ligands are expressed during critical stages of embryonic and postnatal development," researchers in London, the United Kingdom report. "Functional studies in mice, fish, tumor models, and cell culture systems have shown that the angiogenic growth of the blood vessel network, the proliferation of endothelial cells, and the differentiation of arteries and veins are controlled by Notch signaling. Moreover, Notch pathway components play important roles in human pathological conditions involving the vasculature, namely CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and Alagille syndrome," wrote C. Roca and colleagues, Cancer Research UK London Research Institute. The researchers concluded: "Recent findings highlight the Notch ligand Delta-like 4 as a key regulator of tumor angiogenesis and suggest that this protein might be a promising target for cancer therapy." Roca and colleagues published their study in Genes & Development (Regulation of vascular morphogenesis by Notch signaling. Genes & Development, 2007;21(20):2511-24). For additional information, contact C. Roca, Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK. Publisher contact information for the journal Genes & Development is: Cold Spring Harbor Laboratory Press, Publications Dept., 500 Sunnyside Blvd., Woodbury, NY 11797-2924, USA. Keywords: United Kingdom, London, Alagille Syndrome, Angiogenesis, Cancer Research, Oncology, Tumor Vascularization. This article was prepared by Pharma Business Week editors from staff and other reports. Copyright 2007, Pharma Business Week via NewsRx.com.
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