The news correspondents obtained a quote from the research from the University of Glasgow, "As cancer cells express both self- and tumour-associated antigens, Tregs are key to dampening effector cell responses, and therefore represent one of the main obstacles to effective anti-tumour responses. Suppression mechanisms employed by Tregs are thought to contribute significantly to the failure of current therapies that rely on induction or potentiation of anti-tumour responses. This review will focus on the current evidence supporting the central role of Tregs in establishing tumour-specific tolerance and promoting cancer escape. We outline the mechanisms underlying their suppressive function and discuss the potential routes of Tregs accumulation within the tumour, including enhanced recruitment, in-situ or local proliferation, and de-novo differentiation. In addition, we review some of the cancer treatment strategies that act, at least in part, to eliminate or interfere with the function of Tregs."
According to the news reporters, the research concluded: "The role of Tregs is being recognized increasingly in cancer, and controlling the function of these suppressive cells in the tumour microenvironment without compromising peripheral tolerance represents a significant challenge for cancer therapies."
For more information on this research see: Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clinical and Experimental Immunology, 2013;171(1):36-45. Clinical and Experimental Immunology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Clinical and Experimental Immunology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2249)
Our news journalists report that additional information may be obtained by contacting K. Oleinika, University of Glasgow, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Chemokine Res Grp, Glasgow G12 8TA, Lanark, United Kingdom.
Keywords for this news article include: Europe, Glasgow, Oncology, United Kingdom, Cancer Therapy
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