Study data from University of Arkansas provide new insights into colon cancer therapy
2007 NOV 19 -- A new study, 'Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone,' is now available. According to recent research from the United States, "We examined effects of dietary soy protein isolate (SPI) or genistein (GEN; soy isoflavone) during pregnancy on development of colon cancer in male progeny Sprague-Dawley rats. Four groups of rats were used: a lifetime casein-fed group (CAS; control diet), a lifetime SPI-fed group (positive control for protective effect of diet on colon carcinogenesis), a group whose dams received SPI only during pregnancy and CAS thereafter (SPI/CAS), and a group whose dams received CAS+GEN only during pregnancy and CAS thereafter (GEN/CAS)." "At 47 and 55 days of age, male progeny were administered the intestinal carcinogen azoxymethane (AOM). Tumors, endocrine status, and colon gene expression were evaluated at 20 week post-AOM. The SPI group had 47% decreased colon tumor incidence compared with the CAS group (p <0.05), whereas SPI/CAS, GEN/CAS, and CAS groups did not differ in this regard. Maternal-only SPI increased the percentage of animals bearing multiple colon tumors (p <0.05), an effect not mimicked by GEN. Serum insulin and leptin concentrations were decreased by lifetime SPI (p <0.05), whereas serum IGF-I was elevated in the SPI/CAS group (p <0.05). The SPI/CAS group had reduced serum testosterone levels (p <0.05) and exhibited a tendency for increased mucosal expression of IGF-I receptor and glucose transporter-1 mRNAs," wrote R. Xiao and colleagues, University of Arkansas. The researchers concluded: "Results indicate an effect of dietary protein type during pregnancy on colon tumor multiplicity and colon tissue gene expression, and serum IGF-I and testosterone in progeny rats as later adults." Xiao and colleagues published their study in the Journal of Endocrinology (Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone. Journal of Endocrinology, 2007;195(1):79-87). For additional information, contact R. Xiao, University of Arkansas for Medical Sciences, Dept. of Physiology and Biophysics, Little Rock 72205 USA.. Publisher contact information for the Journal of Endocrinology is: Society Endocrinology, 22 Apex Court, Woodlands, Bradley Stoke, Bristol BS32 4JT, England. Keywords: United States, Colon Cancer Therapy, Colon Cancer, Colon Carcinoma, Drugs, Endocrinology, Genistein, IGF I, Oncology, Pharmaceuticals, Testosterone, Therapy, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2007, Biotech Business Week via NewsRx.com.
|
