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Researchers from Kyushu Dental College, Dental College publish new studies and findings in the area of cancer
2009 JUN 1 - (NewsRx.com) -- "It is well known that patients with orofacial cancer suffer from cancer-induced pain which produces feeding difficulties. To understand the mechanisms of pain associated with orofacial cancer, we have recently created a model for rat orofacial cancer by inoculation with Walker carcinosarcoma 256B-cells into the vibrissal pads," investigators in Kitakyushu, Japan report. "The present study used both behavioral and immunohistochemical techniques to investigate changes in pain-related and ingestive behavior, along with c-Fos expression in the medullary dorsal horn which is a site for processing orofacial pain. The tumor mass grew gradually and contacted the nerve trunks within days after the inoculation of tumor cells. Physical difficulties in ingestion were observed after day 10 post-inoculation and facial grooming periods were prolonged. Sensitivities of the inoculated vibrissal pads to mechanical and thermal stimuli were increased on days 4 and 7, suggesting the development of mechanical allodynia and thermal hyperalgesia. Although hyposensitivity to mechanical and thermal stimulation was observed in the inoculated region after day 10, hyperalgesia developed on the margin of the tumor, suggesting that the hypersensitive region spread with growth of tumor mass. In the medullary dorsal horn, the levels of c-Fos immunoreactivity of the ipsilateral side increased significantly on days 4, 7 and 10, supporting the behavioral observations," wrote K. Ono and colleagues, Kyushu Dental College, Dental College. The researchers concluded: "These results indicate that the rat model shows symptoms similar to those in patients with orofacial cancer, for example, induction of feeding disorder and neuropathic pain." Ono and colleagues published their study in European Journal of Pain (Behavioral characteristics and c-Fos expression in the medullary dorsal horn in a rat model for orofacial cancer pain. European Journal of Pain, 2009;13(4):373-379). For additional information, contact O. Nakanishi, Kyushu Dental College, Dept. of Control Physics Functioning, Kokurakita Ku, 2-6-1 Manazuru, Kitakyushu, Fukuoka 8038580, Japan. The publisher of the European Journal of Pain can be contacted at: Elsevier Science Ltd., the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. Keywords: Japan, Kitakyushu, Behavior, Cancer, Carcinosarcoma, Feeding Disorders, Gastroenterology, Neuropathic Pain, Oncology, Orofacial Pain, Speech Pathology, Walker Carcinosarcoma, Kyushu Dental College, Dental College. This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2009, Pain & Central Nervous System Week via NewsRx.com.
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