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Research on heart disease detailed by scientists at Nagoya City University
2009 AUG 24 - (NewsRx.com) -- According to a study from Japan, "Although higher red cell distribution width (RDW) has recently been reported to be associated with increased mortality independent of anemia in patients with heart failure and those with coronary artery disease (CAD), the mechanism underlying this association is Unknown. We hypothesized that higher RDW may reflect neurohumoal activation and a chronic inflammatory state that each contribute to adverse clinical outcomes in these populations." "We measured RDW and plasma levels of B-type natriuretic peptide (BNP) and high-sensitive C-reactive protein (hs-CRP) in 226 consecutive patients Undergoing cardiac catheterization for CAD (age, 67 +/- 8 years; males, 77%; RDW 45.8 +/- 3.3 fL; hemoglobin, 13.2 1.4 g/dL: BNP, median [interquartile range], 26.0 [9.0-58.4] pg/mL; hsCRR 679 [345-1920] ng/mL). Plasma BNP (r = 0.21, P< 0.01) but not hs-CRP (r = 0.04, P> 0.1) levels correlated with RDW. After adjustment for potential confounders including age, gender, body mass index, glomerular filtration rate, hemoglobin. and known hemodynamic determinants of BNP. including elevated left ventricular end-diastolic pressure and volume and slow left ventricular relaxation, RDW was independently predicted by BNP (r(2) = 0.058, P< 0.001)," wrote H. Fukuta and colleagues, Nagoya City University. The researchers concluded: "Elevated BNP levels are independently associated with higher RDW in patients with CAD. Neurohumoral activation may be it mechanistic link between increased RDW and adverse clinical outcomes in this population. (Int Heart J 2009; 50:301-312)." Fukuta and colleagues published their study in International Heart Journal (Elevated Plasma Levels of B-Type Natriuretic Peptide but Not C-Reactive Protein Are Associated With Higher Red Cell Distribution Width in Patients With Coronary Artery Disease. International Heart Journal, 2009;50(3):301-312). For more information, contact H. Fukuta, Nagoya City University, Graduate School of Medicine Science, Dept. of Cardiorenal Med & Hypertension, Mizuho Ku, 1 Kawasumi Mizuho Cho, Aichi 4678601, Japan. Publisher contact information for the International Heart Journal is: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. Keywords: Japan, Angiology, Biotechnology, C Reactive Protein, Cardiology, Coronary Artery Disease, Heart Catheterization, Heart Disease, Heart Failure, Inflammation, Proteomics, Nagoya City University. This article was prepared by Cardiovascular Week editors from staff and other reports. Copyright 2009, Cardiovascular Week via NewsRx.com.
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