New cervical cancer data have been reported by scientists at Xi'an Jiao Tong University, Center for Laboratory Medicine
2007 NOV 19 -- A new study, 'LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway,' is now available. According to a study from People's Republic of China, "It was reported that expression of the estrogen-regulated zinc transporter LIV-1 was particularly high in human cervical cancer cell line HeLa. This result prompted us to study the role that LIV-1 played in human cervical cancer." "The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues. RNAi mediated suppression of LIV-1 in HeLa cells significantly inhibited cell proliferation, colony formation, migration, and invasive ability, but had no effect on cell apoptosis. Furthermore, LIV-1 suppression is accompanied by down-regulation of p44/42 MAPK, phospho-p44/42 MAPK, Snail and Slug expression levels," wrote L. Zhao and colleagues, Xi'an Jiao Tong University, Center for Laboratory Medicine. The researchers concluded: "Hence, our data provide the first evidence that LIV-1 mRNA is overexpressed in cervical cancer in situ and is involved in invasion of cervical cancer cells through targeting MAPK-mediated Snail and Slug expression." Zhao and colleagues published their study in Biochemical and Biophysical Research Communications (LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. Biochemical and Biophysical Research Communications, 2007;363(1):82-8). For more information, contact L. Zhao, The First Affiliated Hospital, Center for Laboratory Medicine, School of Medicine, Xi'an Jiaotong University, Xi'an, China. Publisher contact information for the journal Biochemical and Biophysical Research Communications is: Academic Press Inc. Elsevier Science, 525 B St., Ste. 1900, San Diego, CA 92101-4495, USA. Keywords: People's Republic of China, Biochemical, Cervical Cancer, Cervical Carcinoma, Oncology, Women's Health. This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.
|
