Studies from East Carolina University in the area of perinatology described
2007 NOV 22 -- According to a study from the United States, "Recent reports suggest that specific care strategies improve survival of infants with congenital diaphragmatic hernia ( CDH). This review presents details of care from centers reporting high rates of survival among CDH infants We conducted a MEDLINE search ( 1995 to 2006) and searched all citations in the Cochrane Central Register of Controlled Trials." "Studies were included if they contained reports of > 20 infants with symptomatic CDH, and > 75% survival of isolated CDH Thirteen reports from 11 centers met inclusion criteria. Overall survival, including infants with multiple anomalies, was 603/ 763 ( 79%; range: 69 to 93%). Survival for isolated CDH was 560/ 661 ( 85%; range: 78 to 96%). The frequency of extracorporeal membrane oxygenation ( ECMO) use for isolated CDH varied widely among reporting centers 251/ 622 ( 40%; range: 11 to 61%), as did survival for infants with isolated CDH placed on ECMO: 149/ 206 ( 73%; range: 33 to 86%). There was no suggestion of benefit from use of antenatal glucocorticoids given after 34 weeks gestation or use of postnatal surfactant. Low mortality was frequently attributed to minimizing lung injury and adhering to center- specific criteria for ECMO Use of strategies aimed at minimizing lung injury, tolerance of postductal acidosis and hypoxemia, and adhering to center- specific criteria for ECMO were strategies most consistently reported by successful centers," wrote J.W. Logan and colleagues, East Carolina University. The researchers concluded: "The literature lacks randomized clinical trials of these or other care strategies in this complex patient population; prospective studies of safety and long- term outcome are needed." Logan and colleagues published the results of their research in the Journal of Perinatology (Congenital diaphragmatic hernia: a systematic review and summary of best-evidence practice strategies. Journal of Perinatology, 2007;27(9):535-549). For additional information, contact J.W. Logan, East Carolina University, Bordy School Medical, Division Neonatology Perinatal Medical, 600 Moye Blvd., Greenville, NC 27858, USA. The publisher of the Journal of Perinatology can be contacted at: Nature Publishing Group, 75 Varick Street, 9TH Floor, New York, NY 10013-1917, USA. Keywords: United States, Greenville, Life Sciences, Pediatrics, Perinatology, East Carolina University. This article was prepared by Medical Verdicts & Law Week editors from staff and other reports. Copyright 2007, Medical Verdicts & Law Week via NewsRx.com.
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