Researchers from Nagoya University report on findings in cancer gene therapy
2009 AUG 3 - (NewsRx.com) -- Researchers detail in 'Effect of sonoporation on cationic liposome-mediated IFNbeta gene therapy for metastatic hepatic tumors of murine colon cancer,' new data in cancer gene therapy. "To examine the efficacy of ultrasound-mediated gene therapy in the treatment of hepatic cancer, we performed cationic liposome-mediated interferon-beta (IFNbeta) gene therapy combined with sonoporation, using metastatic hepatic tumors of murine colon cancer. The combination of liposome/DNA treatment and ultrasound gave higher transgene IFNbeta expression in Colon26 colon adenocarcinoma cells than that with microbubble/DNA in combination with ultrasound and that with liposome/DNA alone," scientists in Nagoya, Japan report. "Cationic liposome-mediated IFNbeta gene therapy combined with ultrasound showed an antitumor effect in vitro and combination use of the anticancer drug cis-diamminedichloroplatinum (CDDP) showed a synergistic effect with the IFNbeta gene therapy. The survival of mice with metastatic hepatic tumor of Colon26 cells was significantly prolonged by cationic liposome-mediated IFNbeta gene therapy alone, and sonoporation had a synergistic effect on prolongation of survival and inhibition of tumor growth rate in these mice. Combination use of CDDP with IFNbeta gene therapy also showed a synergistic effect on prolongation of survival and inhibition of tumor growth rate," wrote S. Hayashi and colleagues, Nagoya University. The researchers concluded: "Ultrasound-mediated gene therapy for the treatment of hepatic cancers may be effective in a clinical setting." Hayashi and colleagues published their study in Cancer Gene Therapy (Effect of sonoporation on cationic liposome-mediated IFNbeta gene therapy for metastatic hepatic tumors of murine colon cancer. Cancer Gene Therapy, 2009;16(8):638-43). For more information, contact S. Hayashi, Nagoya University, Dept. of Advanced Medicine in Biotechnology and Robotics, School of Medicine, Showa-ku, Nagoya, Japan. Publisher contact information for the journal Cancer Gene Therapy is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. Keywords: Japan, Nagoya, Adenocarcinoma, Anticancer Therapy, Biotechnology, Cancer Gene Therapy, Colon Cancer, Colon Carcinoma, DNA, Genetics, Genomics, Hepatic Cancer, Hepatic Carcinoma, Interferon, Oncology, Treatment. This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.
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