Colon Cancer

Researchers from Nagasaki University, Department of Translational Medical Sciences report details of new studies and findings in the area of liver cancer prognosis

Colon Cancer Library Library Home This article was published in Clinical Oncology Week, which you can subscribe to online.

"We examined relationships between MVC and clinicopathologic factors or postoperative outcomes in 139 MLC patients who underwent hepatectomy between 1990 and 2006. CD34 expression was analyzed by the immunohistochemical method. MVC was associated with fibrous pseudocapsular formation on histological examination. By means of the modern Japanese classification of liver metastasis, poorer survival was associated with higher score, poorly differentiated adenocarcinoma, higher preoperative carcinoembryonic antigen (CEA) level, fibrous pseudocapsular formation, and smaller surgical margin. Shorter disease-free survival was associated with higher score when the Japanese classification of liver metastasis was used, multiple or bilobar tumor, regional lymph node metastasis in primary colon carcinoma, preoperative CEA level, fibrous pseudocapsular formation, and smaller surgical margin (<5 mm). Higher MVC (>or=406/mm(2)) was associated with decreased disease-free and overall survival by univariate analysis (p=.034 and p=.021, respectively), and higher MVC represented an independently poor prognostic factor in overall survival by Cox multivariate analysis (risk ratio, 2.71; p=.023) in addition to histological differentiation," wrote A. Nanashima and colleagues, Nagasaki University, Department of Translational Medical Sciences.

The researchers concluded: "Tumor MVC seems to be a useful prognostic marker of MLC patient survival."

Nanashima and colleagues published their study in Annals of Surgical Oncology (Clinical significance of microvessel count in patients with metastatic liver cancer originating from colorectal carcinoma. Annals of Surgical Oncology, 2009;16(8):2130-7).

For additional information, contact A. Nanashima, Dept. of Translational Medical Sciences, Division of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Publisher contact information for the journal Annals of Surgical Oncology is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords: Japan, Nagasaki, Liver Cancer Prognosis, Adenocarcinoma, Colon Cancer, Colon Carcinoma, Colorectal, Gastroenterology, Hepatectomy, Hepatocellular Cancer, Hepatocellular Carcinoma, Hepatology, Liver Cancer, Liver Carcinoma, Liver Metastasis, Oncology, Surgery, Surgical Oncology.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2009, Clinical Oncology Week via NewsRx.com.