Colon Cancer

Scientists at Yokohama City University release new data on colon cancer immunology

Colon Cancer Library Library Home This article was published in Clinical Oncology Week, which you can subscribe to online.

"As the tumor doubling time (DT) of hepatic colorectal cancer metastases is a good index of tumor growth, we examined the correlation between tumor DT and the local immune response by phenotype in hepatic colorectal cancer metastases Tumor DT and local immune response were examined in 20 patients with hepatic colorectal cancer metastases by analyzing tumor-infiltrating lymphocytes using flow cytometry or immunohistochemical studies. Tumor proliferative activity was also investigated by determining the expression levels of Ki-67 and proliferating cell nuclear antigen (PCNA) Locally abundant populations of CD83(+) dendritic cells (DCs) and CD8(+) T cells were positively related to longer tumor DT (p <0.05), as were abundant CD8(+) T cells having interferon-gamma-producing potentials (p <0.05)," wrote A. Kito and colleagues, Yokohama City University.

The researchers concluded: "There was no significant correlation between tumor cell expression levels of Ki-67 or PCNA and tumor DT Longer DT tumors have increased local populations of CD8(+) T cells and CD83(+) DCs even in hepatic colorectal cancer metastases."

Kito and colleagues published their study in the Journal of Surgical Oncology (Tumor doubling time and local immune response to hepatic metastases from colorectal cancer. Journal of Surgical Oncology, 2007;96(6):525-33).

For additional information, contact A. Kito, Yokohama City University Graduate School of Medicine, Dept. of Gastroenterological Surgery, Japan.

The publisher's contact information for the Journal of Surgical Oncology is: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA.

Keywords: Japan, Colon Cancer Immunology, Colon Cancer, Colon Carcinoma, Colorectal, Gastroenterology, Immunology, Oncology, Surgical Oncology.

This article was prepared by Clinical Oncology Week editors from staff and other reports. Copyright 2007, Clinical Oncology Week via NewsRx.com.