Reports summarize congenital hypothyroidism research from University libre of Bruxelles
2007 NOV 13 -- Researchers detail in 'Roles of hydrogen peroxide in thyroid physiology and disease,' new data in congenital hypothyroidism. According to a study from Brussels, Belgium, "The long-lived thyroid cell generates, for the synthesis of thyroid hormones, important amounts of H(2)O(2) that are toxic in other cell types. This review analyzes the protection mechanisms of the cell and the pathological consequences of disorders of this system." "EVIDENCE ACQUISITION: The literature on H(2)O(2) generation and disposal, thyroid hormone synthesis, and their control in the human thyroid is analyzed. EVIDENCE SYNTHESIS: In humans, H(2)O(2) production by dual-oxidases and consequently thyroid hormone synthesis by thyroperoxidase are controlled by the phospholipase C-Ca(2+)-diacylglycerol arm of TSH receptor action. H(2)O(2) in various cell types, and presumably in thyroid cells, is a signal, a mitogen, a mutagen, a carcinogen, and a killer. The various protection mechanisms of the thyroid cell against H(2)O(2) are analyzed," wrote Y. Song and colleagues, University libre of Bruxelles. The researchers concluded: "They include the separation of the generating enzymes (dual-oxidases), their coupling to thyroperoxidase in a proposed complex, the thyroxisome, and H(2)O(2) degradation systems It is proposed that various pathologies can be explained, at least in part, by overproduction and lack of degradation of H(2)O(2) (tumorigenesis, myxedematous cretinism, and thyroiditis) and by failure of the H(2)O(2) generation or its positive control system (congenital hypothyroidism)." Song and colleagues published the results of their research in the Journal of Clinical Endocrinology & Metabolism (Roles of hydrogen peroxide in thyroid physiology and disease. Journal of Clinical Endocrinology & Metabolism, 2007;92(10):3764-73). For additional information, contact Y. Song, Universite Libre de Bruxelles, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire (IRIBHM), School of Medicine, Route de Lennik 808, 1070 Brussels, Belgium. The publisher of the Journal of Clinical Endocrinology & Metabolism can be contacted at: Endocrine Society, 8401 Connecticut Avenue, Suite 900, Chevy Chase, MD 20815-5817, USA. Keywords: Belgium, Brussels, Clinical Endocrinology, Congenital Hypothyroidism, Endocrinology, Hormones, Metabolism. This article was prepared by Life Science Weekly editors from staff and other reports. Copyright 2007, Life Science Weekly via NewsRx.com.
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